Characterization of a Novel Barbituric Acid and Two Thiobarbituric Acid Compounds for Lung Cancer Treatment.

Background/aim: Previously, we reported the identification of a cytotoxic chemotype compound CC-I (), a derivative of thiobarbituric acid. We also reported the anticancer activity of a series of novel thio- and seleno-barbituric acid analogs.

Materials And Methods: We herein evaluated the effect of and its modified compounds on in vitro and in vivo lung cancer models.

Results: The compounds and showed more potent cytotoxicity than to lung cancer cells. Moreover, did not have any cytotoxicity on normal cells, such as fibroblasts. In the human lung cancer A549 mouse tumor xenograft model, and showed more pronounced antitumor effects than In the A549 lung cancer cells, induced cell death mainly via JNK and p38 MAPK activation. However, compound and induced lung cancer cell death mostly through JNK activation.

Conclusion: The results suggest that and can be useful therapeutic agents for lung cancer.