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| http://dx.doi.org/10.1016/j.amjsurg.2020.10.027 | DOI Listing |
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As an advanced nucleic acid therapeutical modality, mRNA can express any type of protein in principle and thus holds great potential to prevent and treat various diseases. Despite the success in COVID-19 mRNA vaccines, direct local delivery of mRNA into the lung by inhalation would greatly reinforce the treatment of pulmonary pathogens and diseases. Herein, we developed lipid nanoparticles (LNPs) from degradable ionizable glycerolipids for potent pulmonary mRNA delivery via nebulization.
View Article and Find Full Text PDFResearch review and transcriptomic insights into Benzalkonium chloride inhalation and disease association.
Ecotoxicol Environ Saf
January 2025
College of Pharmacy, Korea University, Sejong 30019, South Korea. Electronic address:
The widespread use of disinfectants, particularly during the coronavirus disease (COVID-19) pandemic, has significantly increased human exposure to biocides, raising concerns about their potential health risks, especially when inhaled. Benzalkonium chloride (BKC), a quaternary ammonium compound commonly used as a disinfectant and preservative, is a notable example because it is frequently used in household products and medical settings. Despite its broad usage, limited research has been conducted on the respiratory and systemic toxicities of BKC.
View Article and Find Full Text PDFAssessing chest radiographic quality and the influence of COVID-19 pathology: the Australian experience.
J Med Radiat Sci
January 2025
Discipline of Medical Imaging Sciences, Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales, Australia.
Introduction: Quality assurance (QA) in medical imaging ensures consistently high-quality images at acceptable radiation doses. However, the applicability of the chest X-ray (CXR) QA tool in images with pathology, particularly infectious diseases like COVID-19, has not been explored. This study examines the utility of the European Guidelines for image quality in QA of CXRs with varying severity and types of infectious disease.
View Article and Find Full Text PDFAchieving inter- and transdisciplinarity in Ecohealth: insights from a rodent-borne disease project in a polycrisis era.
Front Vet Sci
December 2024
Institut national de recherche pour l'agriculture, l'alimentation et l'environnement (INRAE), Paris, France.
Introduction: Inter- and transdisciplinary research (ITDR) is increasingly promoted to address "wicked problems", particularly in health sectors adopting approaches like Ecohealth. Our Ecohealth-inspired project on rodent-borne diseases, initiated just before the COVID-19 pandemic, provided an opportunity to evaluate ITDR implementation.
Methods: We employed a recently developed semi-quantitative evaluation method to measure our project's success in achieving ITDR and analyzed factors influencing this achievement.
SARS-CoV-2 infection of human pluripotent stem cell-derived vascular cells reveals smooth muscle cells as key mediators of vascular pathology during infection.
Nat Commun
December 2024
Whitehead Institute for Biomedical Research, Cambridge, MA, 02142, USA.
Although respiratory symptoms are the most prevalent disease manifestation of infection by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), nearly 20% of hospitalized patients are at risk for thromboembolic events. This prothrombotic state is considered a key factor in the increased risk of stroke, which is observed clinically during both acute infection and long after symptoms clear. Here, we develop a model of SARS-CoV-2 infection using human-induced pluripotent stem cell-derived endothelial cells (ECs), pericytes (PCs), and smooth muscle cells (SMCs) to recapitulate the vascular pathology associated with SARS-CoV-2 exposure.
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