AI Article Synopsis
- - The study aimed to investigate the prevalence of sarcopenia in older adults with hypertension and examine the impact of angiotensin-converting enzyme (ACE) inhibitors on this condition.
- - Out of 272 participants, those with hypertension exhibited a significantly higher frequency of low muscle mass (41.9%) and sarcopenia (32.2%) compared to normotensive individuals, indicating a strong correlation between hypertension and sarcopenia.
- - Notably, the use of ACE inhibitors was associated with a lower prevalence of sarcopenia (8.7%) compared to other antihypertensive medications, suggesting potential protective effects against muscle loss in hypertensive older adults.
Article Abstract
Background: Hypertension and sarcopenia are commonly seen in older adults. The renin-angiotensin system and the therapeutic use of angiotensin-converting enzyme (ACE) inhibitors have been on the agenda of sarcopenia in different perspectives. Our aim was to explore the frequency of sarcopenia in patients with hypertension and to investigate the association between the use of ACE inhibitors and sarcopenia.
Methods: A total of 272 community-dwelling adults were recruited. Anterior thigh muscle thickness was measured by ultrasound. Handgrip strength, gait speed, and chair stand test were evaluated. Low muscle mass was diagnosed in the presence of low sonographic thigh adjustment ratio (STAR) values and sarcopenia was diagnosed if low STAR values were coupled with low functional tests.
Results: 136 subjects (50.0%) had no comorbid disease; 102 (37.5%) had one, 21 (7.7%) had two, nine (3.3%) had three and four (1.5%) had four comorbid diseases. Both low muscle mass (41.9% vs 13.2%) and sarcopenia (32.2% vs 7.8%) were more commonly seen in hypertensive when compared with normotensive older adults. Subgroup analysis of older adults with hypertension revealed that sarcopenia was less prevalent (P = .003) in patients using ACE inhibitors (8.7%) than those using angiotensin II receptor blockers (48.7%) and other antihypertensive drugs (46.4%). After binary logistic regression analyses; only the presence of hypertension seemed to independently predict the development of sarcopenia in older adults [OR = 6.5 (95% CI: 2.4-17.8, P < .001)].
Conclusions: Sarcopenia is highly prevalent in hypertensive older adults. Amongst many antihypertensive medications, ACE inhibitors seem to have favourable effects on both disorders.
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| http://dx.doi.org/10.1111/ijcp.13800 | DOI Listing |
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