A hepatocyte-targeting fluorescent NH probe, GHP, was first designed and synthesized employing N-acetylgalactosamine (GalNAc) as the hepatocyte-targeting group and 3-nitrophthalimide as the recognition moiety. The probe can be used to selectively image NH produced by the hydrolysis of isoniazid in HepG2 cells and the liver of zebrafish in situ.
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| http://dx.doi.org/10.1039/d0cc05330a | DOI Listing |
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