One new tirucallane triterpene named as canarimoic acid (), and three known analogues: 3-hydroxytirucalla-8,24-dien-21-oic acid (), 3-acetyltirucalla-8,24-diene-21oic acid () and 3-oxotirucalla-8,24-dien-21-oic () were isolated from the hydro-ethanolic crude extract of . Their structures were established by extensive analysis of 1 D and 2 D NMR data in conjunction with mass spectrometry and by comparison with those reported in the literature. The evaluation of their antisalmonellal activity using broth microdilution method showed that compound was the most active (MIC =16 µg/mL) against Typhi and Typhimurium followed by compound (MIC= 32 µg/mL) against Typhi and .
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| http://dx.doi.org/10.1080/14786419.2020.1836628 | DOI Listing |
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Canarimoic acid: new tirucallane triterpene with antisalmonellal activity from the stem bark of Engl.
Nat Prod Res
May 2022
Research Unit of Microbiology and Antimicrobial Substances, Faculty of Science, University of Dschang, Dschang, Cameroon.
One new tirucallane triterpene named as canarimoic acid (), and three known analogues: 3-hydroxytirucalla-8,24-dien-21-oic acid (), 3-acetyltirucalla-8,24-diene-21oic acid () and 3-oxotirucalla-8,24-dien-21-oic () were isolated from the hydro-ethanolic crude extract of . Their structures were established by extensive analysis of 1 D and 2 D NMR data in conjunction with mass spectrometry and by comparison with those reported in the literature. The evaluation of their antisalmonellal activity using broth microdilution method showed that compound was the most active (MIC =16 µg/mL) against Typhi and Typhimurium followed by compound (MIC= 32 µg/mL) against Typhi and .
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