Two lanostane dimers, ganoweberianones A () and B (), together with seven previously undescribed lanostanes, ganoweberianic acids A-G (-), and three known compounds (-), were isolated from the artificially cultivated fruiting bodies of the basidiomycete . Ganoweberianone A () exhibited significant antimalarial activity against K1 (multidrug-resistant strain) with an IC value of 0.050 μM. A method for semisynthesis of by condensation of the corresponding lanostane monomers and acid-catalyzed intramolecular transesterification was demonstrated.
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| http://dx.doi.org/10.1021/acs.jnatprod.0c00879 | DOI Listing |
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