AI Article Synopsis
- A systematic review was conducted to evaluate the safety and efficacy of photobiomodulation therapy (PBMT) in cancer patients, following PRISMA guidelines and analyzing 67 studies, including in vitro, in vivo, and clinical research.
- In vitro studies showed mixed results on PBMT's impact on cancer cells, possibly due to varying application parameters, while in vivo studies and clinical trials indicated that PBMT is generally safe and could help prevent complications from cancer treatments.
- Overall, while current literature suggests PBMT may enhance patient survival and safety in certain cancers, additional research is necessary to address unanswered questions and optimize its use in oncology.
Article Abstract
We performed a systematic review of the current literature addressing the safety and efficacy of photobiomodulation therapy (PBMT) in cancer patients. In this systematic review, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used. In vitro, in vivo, and clinical studies, which investigated the effect of PBMT on cell proliferation/differentiation, tumor growth, recurrence rate, and/or overall survival were included. The Medline/PubMed, EMBASE, and Scopus databases were searched through April 2020. A total of 67 studies met the inclusion criteria with 43 in vitro, 15 in vivo, and 9 clinical studies identified. In vitro studies investigating the effect of PBMT on a diverse range of cancer cell lines demonstrated conflicting results. This could be due to the differences in used parameters and the frequency of PBM applications. In vivo studies and clinical trials with a follow-up period demonstrated that PBMT is safe with regards to tumor growth and patient advantage in the prevention and treatment of specific cancer therapy-related complications. Current human studies, supported by most animal studies, show safety with PBMT using currently recommended clinical parameters, including in Head & Neck cancer (HNC) in the area of PBMT exposure. A significant and growing literature indicates that PBMT is safe and effective, and may even offer a benefit in patient overall survival. Nevertheless, continuing research is indicated to improve understanding and provide further elucidation of remaining questions regarding PBM use in oncology.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666741 | PMC |
| http://dx.doi.org/10.1002/cam4.3582 | DOI Listing |
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