Two new compounds classified as one new lumazine peptide, penilumamide K (1) and one new sesquiterpene (2), were obtained from the deep-sea derived fungus Aspergillus sp. SCSIO 41029, together with eleven known compounds (3-13). The structures of 1-13 including absolute configurations were determined by detailed NMR spectroscopy, HR-ESI-MS, chemical derivatization, and optical rotation data. Among them, compound 1 represents the first lumazine peptide reported from deep-sea derived fungus. The bioactive assay exhibited that compounds 1, 3, 4, 5, 7 and 10 had significant potency against α-glucosidase with IC values ranging from 18.61 to 109.06 μΜ. In addition, compounds 4 and 9 showed strong antibacterial activity against Staphylococcus aureus with MIC values of 0.78 and 6.25 μg ml, respectively.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/s41429-020-00378-y | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of marine anoxia on the conversion of macroalgal biomass to refractory dissolved organic carbon.
Mar Environ Res
January 2025
Marine Carbon Sink Research Center, Shandong Marine Resource and Environment Research Institute, Yantai, 264006, China; College of Oceanography and Ecological Science, Shanghai Ocean University, Shanghai, 201306, China.
The input of macroalgal biomass into the deep sea is a crucial process for macroalgal carbon sequestration, but this process may be affected by anoxia. We compared the breakdown of kelp biomass in both normoxic (>4 mg/L O) and anoxic (<2 mg/L O) environments. Following 240 days of decomposition experiment, complete degradation of the kelp biomass occurred in normoxic conditions, whereas under anoxic conditions, relatively 13.
View Article and Find Full Text PDFCold-active enzymes from deep marine psychrophiles: harnessing their potential in enhanced food production and sustainability.
Crit Rev Biotechnol
January 2025
Department of Animal Biotechnology, Faculty of Biotechnology, College of Applied Life Sciences, Jeju National University, Jeju Special Self-Governing Province, Republic of Korea.
Exploring the untapped potential of deep-sea microorganisms, particularly their cold-active enzymes, or psychrozymes, offers exciting possibilities for revolutionizing various aspects of the food processing industry. This review focuses on these enzymes, derived from the largely unexplored depths of the deep ocean, where microorganisms have developed unique adaptations to extreme conditions. Psychrozymes, as bioactive molecules, hold significant promise for food industry applications.
View Article and Find Full Text PDFAntibacterial and Cytotoxic Methylthioether-Containing Cytochalasins from AS-506, an Endozoic Fungus Associated with Deep-Sea Sponge of Magellan Seamounts.
J Agric Food Chem
January 2025
CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China.
Ten cytochalasin derivatives, including six new methylthioether-containing chaetoglobosins (thiochaetoglobosins A-F, ), a new related congener (18-nor-prochaetoglobosin II, ), and three known unsulfured counterparts (), were isolated and identified from AS-506, an endozoic fungus isolated from a deep-sea sponge, which was collected from Magellan Seamounts in the Western Pacific Ocean. Their structures were determined by extensive interpretation of the spectroscopic and X-ray crystallographic data, as well as by ECD calculations. Structurally, thiochaetoglobosins A-F () represent the first examples of chaetoglobosin derivatives containing a methylthioether group in the molecules, while 18-nor-prochaetoglobosin II () is the first 18-nor-chaetoglobosin derivative.
View Article and Find Full Text PDFFrom the depths of the Java Trench: genomic analysis of Priestia flexa JT4 reveals bioprospecting and lycopene production potential.
BMC Genomics
December 2024
Institut Teknologi Bandung, School of Life Sciences and Technology, Bandung, West Java, Indonesia.
Background: The marine environment boasts distinctive physical, chemical, and biological characteristics. While numerous studies have delved into the microbial ecology and biological potential of the marine environment, exploration of genetically encoded, deep-sea sourced secondary metabolites remains scarce. This study endeavors to investigate marine bioproducts derived from deep-sea water samples at a depth of 1,000 m in the Java Trench, Indonesia, utilizing both culture-dependent and whole-genome sequencing methods.
View Article and Find Full Text PDFThree new terpenoid derivatives from the deep-sea-derived fungus DFFSCS007.
J Asian Nat Prod Res
December 2024
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
Three new terpenoid derivatives (1,6,7)-hydrobenzosydowic acid (), (1 ,6,7)-hydrobenzosydowic acid (), and (7 ,10)-11-dehydroxy-iso-10-hydroxysydowic acid (), along with the known analogues ()-2-(1-(4-nitrobenzoyl)pyrrolidine-2-carboxamido)benzoic acid () and trihydroxybutyl ester of 4-carboxydiorcinol () were isolated from the deep-sea-derived fungus DFFSCS007. Their structures were determined by spectroscopic analysis. Compound with a nitrobenzene group was isolated from nature for the first time.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!