Pelletierine, a proposed building block of alkaloids (LAs), was demonstrated to be synthesized via the non-enzymatic Mannich-like condensation of Δ-piperideine and 3-oxoglutaric acid produced by two new type III PKSs (HsPKS4 and PcPKS1) characterized from and , respectively. The findings provide new insights for further understanding the biosynthesis of LAs such as huperzine A.
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