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http://dx.doi.org/10.1016/j.hrcr.2020.07.002 | DOI Listing |
J Chem Inf Model
January 2025
Department of Computer Science and Technology, Shantou University, Shantou 515063, China.
The human microbiota may influence the effectiveness of drug therapy by activating or inactivating the pharmacological properties of drugs. Computational methods have demonstrated their ability to screen reliable microbe-drug associations and uncover the mechanism by which drugs exert their functions. However, the previous prediction methods failed to completely exploit the neighborhood topologies of the microbe and drug entities and the diverse correlations between the microbe-drug entity pair and the other entities.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
January 2025
Institute for Applied Mathematics, University of Bonn, Bonn, Germany.
Purpose: To quantify outer retina structural changes and define novel biomarkers of inherited retinal degeneration associated with biallelic mutations in RPE65 (RPE65-IRD) in patients before and after subretinal gene augmentation therapy with voretigene neparvovec (Luxturna).
Methods: Application of advanced deep learning for automated retinal layer segmentation, specifically tailored for RPE65-IRD. Quantification of five novel biomarkers for the ellipsoid zone (EZ): thickness, granularity, reflectivity, and intensity.
Invest Ophthalmol Vis Sci
January 2025
Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Purpose: This study aimed to identify a novel recombinant adeno-associated virus (rAAV) capsid variant that can widely transfect the deep retina through intravitreal injection and to assess their effectiveness and safety in gene delivery.
Methods: By adopting the sequences of various cell-penetrating peptides and inserting them into the capsid modification region of AAV2, we generated several novel variants. The green fluorescent protein (GFP)-carrying variants were screened following intravitreal injection.
Methods Mol Biol
January 2025
Charité Universitätsmedizin Berlin, Berlin, Germany.
A key goal of biology is to understand the origin of the many cell types that can be observed during diverse processes such as development, regeneration, and disease. Single-cell RNA-sequencing (scRNA-seq) is commonly used to identify cell types in a tissue or organ. However, organizing the resulting taxonomy of cell types into lineage trees to understand the origins of cell states and relationships between cells remains challenging.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
January 2025
Department of Environmental Biotechnology, Faculty of Energy and Environmental Engineering, Silesian University of Technology, Akademicka Str. 2, 44-100, Gliwice, Poland.
Various novel technologies are currently under development aimed at improving bio-methane output to tackle challenges related to process stability, biogas production, and methane quality in the anaerobic digestion (AD) process. The management of substrate type, temperature, pH, hydraulic retention time (HRT), organic loading rate (OLR), and inoculum origin is essential for ensuring process effectiveness, minimizing inhibition, and maximizing production of biogas and methane yield. The review emphasizes sustainability, focusing on the environmental and economic benefits of anaerobic digestion, including the reduction of greenhouse gas (GHG) emissions, the minimization of landfill waste, and the provision of renewable energy sources.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!