Sarcoidosis and lymphoma are two separate entities that need to be considered in the differential diagnosis of lymphadenopathy. Rarely these two diseases may coexist, in which case there may arise a diagnostic challenge, especially when the available sample is limited. We report a case of occult mantle cell lymphoma arising in an individual with a long history of sarcoidosis.
Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón. Madrid, Spain; CIBERES, CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
The clinical presentation of SARS-CoV-2 infection is often more severe and persistent in immunosuppressed hosts. We present the case of a patient with mantle cell lymphoma under treatment with rituximab and ibrutinib who had multiple hospitalizations with pulmonary infiltrates following mild SARS-CoV-2 infection and repeated negative nasopharyngeal (NP) RT-PCR tests. SARS-CoV-2 was eventually detected in bronchoalveolar lavage fluid and the symptoms resolved after treatment with remdesivir.
We report a case of mantle cell lymphoma mimicking Castleman disease. A 76-year-old man presented with generalized lymphadenopathy, splenomegaly, anemia, polyclonal gammopathy, and pulmonary infiltrations. Lymph node biopsy revealed histological features of hyaline vascular Castleman disease.
Sarcoidosis and lymphoma are two separate entities that need to be considered in the differential diagnosis of lymphadenopathy. Rarely these two diseases may coexist, in which case there may arise a diagnostic challenge, especially when the available sample is limited. We report a case of occult mantle cell lymphoma arising in an individual with a long history of sarcoidosis.
. Mantle cell lymphoma (MCL) comprises approximately 3% to 10% of all non-Hodgkin lymphomas. Although there is an increased risk for secondary malignancies after treatment among non-Hodgkin lymphomas survivors, a synchronous diagnosis of primary lung cancer arising in conjunction with lymphoma at the same site has rarely been reported.
From the Department of Radiology, Royal Marsden NHS Foundation Trust, Downs Rd, Sutton, Surrey SM2 5PT, England (S.D.A.); Cambridge Breast Unit and NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Cambridge, Cambridgeshire, England (M.G.W.); and Divisions of Genetics and Epidemiology (R.C., A.J.S.) and Breast Cancer Research (A.J.S.), Institute of Cancer Research, Sutton, Surrey, England.
Purpose: To retrospectively review diagnostic mammography in women diagnosed with breast cancer who previously had mantle field radiation therapy for Hodgkin disease in England and Wales over a period of 30 years.
Materials And Methods: From a national cohort study of 5002 women treated with supradiaphragmatic radiation therapy when they were younger than 36 years (mean, 22.1 years) during 1956-2003, 392 patients developed breast cancer.
