The metaphorical adoption of the concepts of information, program and signal introduced into biology the logic and implicit causal structure of the mathematical theories of information; this is inimical to biology. In turn, those metaphors have hindered the development of a theory of organisms by transferring the agency of organisms to natural selection and to DNA. Moreover, those metaphors introduced into biology the dualism software-hardware and a Laplacian causal structure. Instead, we propose to uphold the agency of the living by adopting three foundational principles for a theory of organisms: namely, 1) the principle of biological inertia (i.e., the default state of cells is proliferation and motility), 2) the principle of variation, and 3) the principle of organization.
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http://dx.doi.org/10.1080/03080188.2020.1794389 | DOI Listing |
Strateg Organ
February 2025
In this contribution, we theorize generativity as a heuristic for impact-driven management scholars seeking to address grand challenges through research. We use generativity to connote the engagement of diverse actors in pluralistic inquiry to create conditions for future flourishing. Our theorization applies a pragmatist worldview and builds on insights from the multidisciplinary literature on generativity to envisage researchers as agents of care, collective learning, and transformative change.
View Article and Find Full Text PDFAnim Microbiome
January 2025
Genomics & Bioanalytics, Los Alamos National Laboratory, Los Alamos, NM, 87506, USA.
Background: African buffalo (Syncerus caffer) is a significant reservoir host for many zoonotic and parasitic infections in Africa. These include a range of viruses and pathogenic bacteria, such as tick-borne rickettsial organisms. Despite the considerations of mammalian blood as a sterile environment, blood microbiome sequencing could become crucial for agnostic biosurveillance.
View Article and Find Full Text PDFJ Clin Med
December 2024
Radiology Department, Faculty of Medicine, Kahramanmaras Sutcu Imam University, 46050 Kahramanmaras, Türkiye.
Malnutrition is a common health problem affecting overall body functions, growth, and development. The aim of the present study was to explore any potential changes in solid organ sizes due to malnutrition and, if so, their correlation with the degree of malnutrition. Solid organ sizes (liver, spleen, and kidneys) in patients with primary malnutrition were measured prospectively using ultrasonography.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Laboratory of Molecular Oncology and Innovative Therapies, Military Institute of Medicine National Research Institute, 128 Szaserów Street, 04-141 Warsaw, Poland.
Advancements in single-cell analyzis technologies, particularly single-cell RNA sequencing (scRNA-seq) and Fluorescence-Activated Cell Sorting (FACS), have enabled the analyzis of cellular diversity by providing resolutions that were not available previously. These methods enable the simultaneous analyzis of thousands of individual transcriptomes, facilitating the classification of cells into distinct subpopulations, based on transcriptomic differences, adding a new level of complexity to biomolecular and medical research. Fibroblasts, despite being one of the most abundant cell types in the human body and forming the structural backbone of tissues and organs, remained poorly characterized for a long time.
View Article and Find Full Text PDFPublic Health Nurs
January 2025
Department of Gastrointestinal Surgery, Peking University Shenzhen Hospital, Shenzhen, China.
Aim: The aim of this systematic review is to present the pooled estimated prevalence and risk factors for cognitive impairment (CI) in patients with chronic obstructive pulmonary disease (COPD).
Background: Patients with COPD suffer from progressive and irreversible airflow limitation, resulting in continuous impairment of lung function, which in addition to causing lesions in the lungs, often accrues to other organs as well. In recent years, a growing number of cross-sectional and longitudinal studies have shown that hypoxia is an important factor in causing CI and that there is an important link between them, but the assessment of co-morbid neurocognitive impairment and dysfunction is often overlooked.
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