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http://dx.doi.org/10.14639/0392-100X-N0443 | DOI Listing |
J Appl Physiol (1985)
January 2025
Centre for Heart, Lung and Vascular Health, University of British Columbia - Okanagan Campus, Kelowna, BC, Canada.
Serotonin (5-HT) is integral to signalling in areas of the brainstem controlling ventilation and is involved in central chemoreception. Selective serotonin reuptake inhibitors (SSRIs), used to effectively increase 5-HT concentrations, are commonly prescribed for depression. The effects of SSRIs on the control of breathing and the potential influence of cerebral blood flow (CBF) have not been directly assessed.
View Article and Find Full Text PDFAm J Physiol Lung Cell Mol Physiol
December 2024
The author is retired. The positions and affiliations are those prior to his retirement.
Important insights and consensus remain lacking for risk prediction of opioid-induced respiratory depression (OIRD), reversal of respiratory depression (RD), the pathophysiology of OIRD, and which sites make the most significant contribution to its induction. The ventilatory response to inhaled carbon dioxide is the most sensitive biomarker of OIRD. To accurately predict respiratory depression (RD), a multivariant RD prospective trial using continuous capnograph and oximetry examining 5 independent variables: age ≥60, sex, opioid naivety, sleep disorders, and chronic heart failure (PRODIGY trial), was undertaken.
View Article and Find Full Text PDFCan J Cardiol
November 2024
Fisher Institute of Health and Well-Being, Ball State University, Muncie, Indiana, USA.
J Funct Morphol Kinesiol
November 2024
Institute of Human Movement Science, Sport & Health, University of Graz, 8010 Graz, Austria.
: The impact of exercise on affective disorders has been demonstrated in various studies. However, almost no data are available on performance effects. Therefore, this study investigated exercise performance related to the severity of depression symptoms in a pre-post within-subjects design in a 6-week standard inpatient psychiatric rehabilitation program.
View Article and Find Full Text PDFJ Perioper Pract
October 2024
Department of Anaesthesia, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK.
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