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Proteomics of circulating extracellular vesicles reveals diverse clinical presentations of COVID-19 but fails to identify viral peptides.
Front Cell Infect Microbiol
November 2024
ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
Article Synopsis
- Extracellular vesicles (EVs) from virus-infected cells could aid in vaccine development by encapsulating viral peptides and indicating tissue changes in infections.
- Blood samples from severe COVID-19 patients, mild cases, and uninfected healthcare workers were collected to analyze the molecular characteristics of EVs and identify suitable vaccine peptides.
- Despite the expectation to find viral peptides, the proteomic analysis revealed no such findings, but highlighted a diverse EV cargo linked to inflammation and viral replication, suggesting EVs play a significant role in COVID-19 pathology.
Single-cell transcriptome analysis reveals atypical monocytes circulating ahead of acute graft-versus-host disease clinical onset.
J Leukoc Biol
October 2024
Swiss Federal Institute of Technology Lausanne (Ecole Polytechnique Fédérale de Lausanne, EPFL), School of Life Sciences, Laboratory of Virology and Genetics (LVG), EPFL-SV-GHI-LVG, Station 11, CH-1015 Lausanne, Switzerland.
Acute graft-versus-host disease (aGVHD) represents the rejection of the recipient's skin, gut, and liver tissues of an allogeneic hematopoietic stem cell transplantation (HSCT) by the donor T-cells. The onset of aGVHD is often rapid and its evolution is unpredictable. We undertook the single-cell RNA sequencing of peripheral blood mononuclear cells (PBMCs) collected before aGVHD clinical onset in three patients and from one patient afterward.
View Article and Find Full Text PDFIntra-patient spatial comparison of non-metastatic and metastatic lymph nodes reveals the reduction of CD169 macrophages by metastatic breast cancers.
EBioMedicine
September 2024
Department of Breast Surgery, Kyoto University Hospital, Graduate School of Medicine, Shogoin Sakyo-ku, Kyoto 606-8507, Japan; Department of Breast Surgery, Breast Center, Mie University, Mie 514-0102, Japan. Electronic address:
Background: Breast cancer cells suppress the host immune system to efficiently invade the lymph nodes; however, the underlying mechanism remains incompletely understood. Here, we aimed to comprehensively characterise the effects of breast cancers on immune cells in the lymph nodes.
Methods: We collected non-metastatic and metastatic lymph node samples from 6 patients with breast cancer with lymph node metastasis.
CD169 Skin Macrophages Function as a Specialized Subpopulation in Promoting Psoriasis-like Skin Disease in Mice.
Int J Mol Sci
May 2024
Department of Immunology and Microbiology, Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Skin macrophages are critical to maintain and restore skin homeostasis. They serve as major producers of cytokines and chemokines in the skin, participating in diverse biological processes such as wound healing and psoriasis. The heterogeneity and functional diversity of macrophage subpopulations endow them with multifaceted roles in psoriasis development.
View Article and Find Full Text PDFSialic Acid-Siglec-E Interactions Regulate the Response of Neonatal Macrophages to Group B Streptococcus.
Immunohorizons
May 2024
Department of Pediatrics, Stanford University, Palo Alto, CA.
The mammalian Siglec receptor sialoadhesin (Siglec1, CD169) confers innate immunity against the encapsulated pathogen group B Streptococcus (GBS). Newborn lung macrophages have lower expression levels of sialoadhesin at birth compared with the postnatal period, increasing their susceptibility to GBS infection. In this study, we investigate the mechanisms regulating sialoadhesin expression in the newborn mouse lung.
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