AI Article Synopsis
- - Kidney involvement is common in immunoglobulin-related amyloidosis (AIg), showing significant effects on quality of life, though it's generally less fatal than cardiac amyloidosis.
- - The causes and mechanisms of kidney issues in AIg are still not fully understood, but there are models to help predict outcomes and responses to treatment.
- - Patients with severe kidney damage face a poor prognosis, highlighting the need for improved therapies, while those with end-stage renal disease may benefit from kidney transplantation.
Article Abstract
Kidney involvement in immunoglobulin-related amyloidosis (AIg) is common. Although patients with renal-limited AIg tend not to have the high mortality that patients with cardiac amyloidosis have, they do experience significant morbidity and impact on quality of life. The complexity of the pathogenesis remains incompletely understood. Models have been established to prognosticate and assess for the response to therapy. Patients with advanced renal impairment from immunoglobulin light chain amyloidosis still have poor renal prognosis, and better therapy is needed in order to preserve kidney function. Patients who develop end-stage renal disease can undergo renal replacement therapy with kidney transplantation.
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| http://dx.doi.org/10.1016/j.hoc.2020.08.002 | DOI Listing |
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