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Prolonged Hypoxia in Rat Living Myocardial Slices Affects Function, Expression, and Structure.
Int J Mol Sci
December 2024
Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, 30625 Hannover, Germany.
Ischemic heart disease is the leading cause of death worldwide. Reduced oxygen supply and myocardial hypoxia lead to tissue damage and impairment of the heart function. To the best of our knowledge, the primary functional effects of hypoxia in the multicellular model of living myocardial slices (LMSs) have not been investigated so far.
View Article and Find Full Text PDFResponse of Crop Yield and Productivity Contribution Rate to Long-Term Different Fertilization in Northeast of China.
Plants (Basel)
January 2025
Heilongjiang Academy of Black Soil Conservation and Utilization, Harbin 150086, China.
To reveal the changes in crop yield and contribution rate of black soil productivity under long-term different fertilization conditions in black soil areas and to find the important significance of fertilization for sustainable and stable crop yield, high yield, and improving the contribution rate of black soil nutrients. Based on the long-term experiment of black soil fertility in Harbin, the Ministry of Agriculture and Rural Affairs, under the maize-wheat-soybean rotation system, crop yield, sustainability and stability of yield, the contribution rate of black soil productivity, and natural nutrient supply capacity under 10 fertilization treatments (CK, NP, NK, PK, NPK, M, MNP, MNK, MPK, and MNPK) were analyzed. Results showed that, compared with the treatment of chemical fertilizer, yields of maize, wheat, and soybeans increased under treatment of organic fertilizer combined with chemical fertilizer, among which the yields of maize and wheat changed the most.
View Article and Find Full Text PDFEffect of Hypoglycemia on QT Interval in Individuals with and without Type 2 Diabetes: A Randomized Crossover Trial.
J Clin Endocrinol Metab
January 2025
Harvard Medical School, Boston, MA, USA.
Background: Our goal was to determine in healthy individuals and individuals with type 2 diabetes the impact of repeated episodes of hypoglycemia on the corrected QT (QTc) interval and the time course for QTc recovery. Further, since hypoglycemia increases aldosterone and patients with primary aldosteronism have prolonged QTc, we also determined whether mineralocorticoid receptor blockade prevents hypoglycemia-induced QTc alterations.
Methods: Twenty-seven healthy participants completed a double-blinded crossover trial contrasting 3 experimental conditions: 1) euglycemia, 2) hypoglycemia, and 3) hypoglycemia with mineralocorticoid receptor blockade pretreatment.
Comparative analysis of adenosine 1 receptor expression and function in hippocampal and hypothalamic neurons.
Inflamm Res
January 2025
Medical Faculty and University Hospital, Institute of Neural and Sensory Physiology, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.
Background: Adenosine, an ATP degradation product, is a sleep pressure factor. The adenosine 1 receptor (A1R) reports sleep need. Histaminergic neurons (HN) of the tuberomamillary nucleus (TMN) fire exclusively during wakefulness and promote arousal.
View Article and Find Full Text PDFSpinal cord gray matter atrophy is associated with disability in spinal muscular atrophy.
J Neurol
January 2025
Department of Neurology, University Hospital Basel, University of Basel, Basel, Switzerland.
Background: With the approval of disease-modifying treatments for 5q-spinal muscular atrophy (SMA), there is an increasing need for biomarkers for disease course and therapeutic response monitoring. Radially sampled Averaged Magnetization Inversion Recovery Acquisitions (rAMIRA) MR-imaging enables spinal cord (SC) gray matter (GM) delineation and quantification in vivo. This study aims to assess SC GM atrophy in patients with 5q-SMA and its associations with clinical disability.
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