The origins, development, and status of the pi mechanism theory are reviewed. The paper is divided into four sections. In the first section Stiles's general ideas about 'color mechanisms' are examined, and it is concluded that foremost amongst these is a mathematical theory that specifies certain formal rules or laws that should govern a certain class of observations. In the case of pi mechanisms, the class of observations is that of two-color thresholds, and the defining laws are the two well-known displacement laws. Five other laws that two-color increment-threshold observations should obey, if the latter are governed by ideal pi mechanisms, are abstracted from Stiles's writings. In the second section literature pertinent to the testing of the seven Stilesian laws is reviewed, and it is asked whether or not the seven pi mechanisms of Stiles do in fact obey the laws. In the third section the relation of the pi mechanism concept to physiological concepts is examined, and its relation to the 'cone fundamental' is discussed; the evidence pertinent to the question: "Are any of the pi mechanisms of the single-fundamental type?" is then reviewed. The last section is devoted to the evolution of Stiles's ideas in the period after 1959 when Stiles's own investigations and those of others propelled him to reject the initial (1953) pi mechanism theory as an adequate characterization of the data of the two-color threshold.
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JAMA Netw Open
January 2025
University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Importance: A substantial number of individuals worldwide experience long COVID, or post-COVID condition. Other postviral and autoimmune conditions have a female predominance, but whether the same is true for long COVID, especially within different subgroups, is uncertain.
Objective: To evaluate sex differences in the risk of developing long COVID among adults with SARS-CoV-2 infection.
Alzheimers Dement (Amst)
January 2025
Introduction: This study examined whether sex differences in verbal learning and memory (VLM) are mediated by plasma brain-derived neurotrophic factor (BDNF) expression.
Methods: In a sample of = 201 participants (63.81 ± 6.
bioRxiv
November 2024
Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA.
The interplay of RNA modifications - deposited by "writers", removed by "erasers" and identified by RNA binding proteins known as "readers" - forms the basis of the epitranscriptomic gene regulation hypothesis. Recent studies have identified the oncofetal RNA-binding protein IGF2BP3 as a "reader" of the N6-methyladenosine (mA) modification and crucial for regulating gene expression. Yet, how its function as a reader overlaps with its critical oncogenic function in leukemia remains an open question.
View Article and Find Full Text PDFJ Trauma Acute Care Surg
January 2025
From the Department of Surgery (K.D.N., D. Tatum, A.P., J.C.D., A.S.A., E.I., B.M., E.C., S.T.), Tulane University School of Medicine, New Orleans, Louisiana; Department of Surgery (K.D.N.), Harbor-UCLA Medical Center, Torrance, California; Department of Surgery (M.B.P., A.W.M., A.B.P.), Vanderbilt University Medical Center, Nashville, Tennessee; Department of Surgery (J.N., C.A.), University of California-Irvine, Orange, California; Department of Surgery (P.O.U., A. Stiles, C.S.), Wake Med, Raleigh, North Carolina; Department of Surgery (J.D. Stodghill, T.M.), Virginia Tech Carilion School of Medicine, Roanoke, Virginia; Department of Surgery (R.M.B., S.A.Z., B. Shammassian, A.A.S.), Louisiana State University Health, New Orleans, Louisiana;Department of Surgery (T.E., I.A., P.M., J. Metheny), Cooper Medical School of Rowan University, Camden, New Jersey; Department of Surgery (M.S.F., M.D.P.), Lehigh Valley Health Network, Allentown, Pennsylvania; Department of Surgery (O.T.M., P.S.), Valleywise Health Medical Center, Phoenix, Arizona; Department of Surgery (D.T.-W.W., J.S.), Arrowhead Regional Medical Center, Colton, California; Department of Surgery (J.D. Sciarretta, P.K.), Emory University School of Medicine, Atlanta, Georgia; Department of Surgery (R.H., D.G.), Loma Linda University Medical Center, Loma Linda, California; Department of Surgery (J. Murry, K. Meadows), UT Health Tyler, Tyler, Texas; Department of Surgery (L.E.J., J.M.W.), Ascension St. Vincent Hospital, Indianapolis, Indiana; Department of Surgery (A.C.B.), University of Kentucky Healthcare, Lexington, Kentucky;17 DeBusk College of Osteopathic Medicine (B. Smith), Lincoln Memorial University, Harrogate, Tennessee; Department of Surgery (S.L.M., N.P.), Conemaugh Memorial Medical Center, Johnstown, Pennsylvania; Department of Surgery (D. Tabello, E.T.), Inova Health System, Falls Church, Virginia; Department of Surgery (S.M.C., F.A.), King Saud Medical City, Riyadh, Saudi Arabia;Department of Surgery (B.S.M., M.A.W.), University of Minnesota, Minneapolis, Minnesota;22 Department of Surgery (T.H.J., G.D.), Our Lady of the Lake Regional Medical Center, Baton Rouge, Louisiana;23 Department of 'Surgery (J.A.M., D.R.), Thomas Jefferson University Hospital, Philadelphia, Pennsylvania;24 Department of Surgery (J.M.H., K.L.), Ascension Via Christi Hospitals Wichita, Wichita, Kansas;25 Department of Surgery (K. Matsushima, S.P.), Los Angeles General Medical Center, Los Angeles, California; Department of Surgery (A. Santos, K.S.), Texas Tech University Health Science Center; Department of Surgery (C.B.), Covenant Medical Center, Lubbock, Texas; Department of Surgery (R.S., S.V.), Bronson Methodist Hospital, Kalamazoo, Michigan; Department of Surgery (R.J.J., R.C.H.), College of Medicine Chattanooga, University of Tennessee, Chattanooga, Tennessee; Department of Surgery (S.L.), Warren Alpert Medical School at Brown University, Providence, Rhode Island; Department of Surgery (N.B., W.A.), Tufts Medical Center, Boston, Massachusetts; Department of Surgery (M.J.L., H.M.), Research Medical Center, Kansas City, Missouri; Department of Surgery (R.P.D., C.A.F.), University of Texas Southwestern Medical Center, Dallas, Texas; Department of Surgery (C.A.F.), Brody School of Medicine at East Carolina, Greenville, North Carolina; Department of Surgery (W.T.H.T., Y.T.), University of Nebraska Medical Center, Omaha, Nevada; Department of Surgery (V.M., F.M.), U General University Hospital of Patras, Pio, Greece; and Department of Surgery (J.D.B., D.R.M.), Broward Health Medical Center, Fort Lauderdale, Florida.
Proc Natl Acad Sci U S A
September 2024
Stiles-Nicholson Brain Institute, Florida Atlantic University, Jupiter, FL 33458.
Cuprous copper [Cu(I)] is an essential cofactor for enzymes that support many fundamental cellular functions including mitochondrial respiration and suppression of oxidative stress. Neurons are particularly reliant on mitochondrial production of ATP, with many neurodegenerative diseases, including Parkinson's disease, associated with diminished mitochondrial function. The gene encodes a ribonuclease that targets pre-mRNA of replication-dependent histones, proteins recently found in yeast to reduce Cu(II) to Cu(I), and when mutated disrupt ATP production, elevates oxidative stress, and severely impacts cell growth.
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