AI Article Synopsis

  • The review discusses the use of stellate ganglion blockade (SGB) as a treatment for patients with severe ventricular arrhythmias that don't respond to other therapies.
  • SGB can significantly reduce the frequency of arrhythmias and defibrillation events for 24-72 hours, providing a critical window for additional treatments like catheter ablation or heart surgery.
  • The procedure is shown to be safe, even in patients on anticoagulants, and is effective across different types and causes of ventricular arrhythmias.

Article Abstract

Purpose Of Review: To highlight the indications, procedural considerations, and data supporting the use of stellate ganglion blockade (SGB) for management of refractory ventricular arrhythmias.

Recent Findings: In patients with refractory ventricular arrhythmias, unilateral or bilateral SGB can reduce arrhythmia burden and defibrillation events for 24-72 h, allowing time for use of other therapies like catheter ablation, surgical sympathectomy, or heart transplantation. The efficacy of SGB appears to be consistent despite the type (monomorphic vs polymorphic) or etiology (ischemic vs non-ischemic cardiomyopathy) of the ventricular arrhythmia. Ultrasound-guided SGB is safe with low risk for complications, even when performed on anticoagulation. SGB is effective and safe and could be considered for patients with refractory ventricular arrhythmias.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646199PMC
http://dx.doi.org/10.1007/s11906-020-01111-8DOI Listing

Publication Analysis

Top Keywords

ventricular arrhythmias
12
refractory ventricular
12
stellate ganglion
8
ganglion blockade
8
patients refractory
8
ventricular
5
sgb
5
blockade intervention
4
intervention management
4
management ventricular
4

Similar Publications

Automated Classification of Cardiac Arrhythmia using Short-Duration ECG Signals and Machine Learning.

Biomed Phys Eng Express

January 2025

Electronics and Communication Engineering, Rajiv Gandhi University, Rono Hills, Doimukh, ITANAGAR, Itanagar, Arunachal Pradesh, 791112, INDIA.

Accurate detection of cardiac arrhythmias is crucial for preventing premature deaths. The current study employs a dual-stage Discrete Wavelet Transform (DWT) and a median filter to eliminate noise from ECG signals. Subsequently, ECG signals are segmented, and QRS regions are extracted for further preprocessing.

View Article and Find Full Text PDF

Monopolar electrocautery is usually a safe and effective technique used in laparoscopic cholecystectomy and bile duct surgery, but it may lead to adverse consequences, even ventricular fibrillation (VF). Amiodarone is an effective antiarrhythmic drug commonly used in practice to treat ventricular and atrial arrhythmias, but it may induce tachyarrhythmia or even VF. We report a case of VF occurring twice during cholecystectomy.

View Article and Find Full Text PDF

Obscurin is a giant protein that coordinates diverse aspects of striated muscle physiology. Obscurin immunoglobulin domains 58/59 (Ig58/59) associate with essential sarcomeric and Ca2+ cycling proteins. To explore the pathophysiological significance of Ig58/59, we generated the Obscn-ΔIg58/59 mouse model, expressing obscurin constitutively lacking Ig58/59.

View Article and Find Full Text PDF

Is hypercalcemia immediately life-threatening ? A prospective study.

Endocr Connect

January 2025

C Guimard, Department of Medicine, Clinique Jules Verne, Nantes, France.

Objective: Hypercalcemia is often considered as an emergency because of a potential risk life-threatening arrhythmias or coma. However, there is little evidence, apart from case studies, that hypercalcemia can be immediately life-threatening. The aim of our study was to assess prospectively, if hypercalcemia (Ca ≥ 3 mmol/L) was associated with immediately life-threatening complications.

View Article and Find Full Text PDF

The Role of RyR2 Mutations in Congenital Heart Diseases: Insights Into Cardiac Electrophysiological Mechanisms.

J Cardiovasc Electrophysiol

January 2025

Department of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.

Ryanodine receptor 2 (RyR2) protein, a calcium ion release channel in the sarcoplasmic reticulum (SR) of myocardial cells, plays a crucial role in regulating cardiac systolic and diastolic functions. Mutations in RyR2 and its dysfunction are implicated in various congenital heart diseases (CHDs). Studies have shown that mutations in the RYR2 gene, which encodes the RyR2 protein, are linked to several cardiac arrhythmias, including catecholaminergic polymorphic ventricular tachycardia (CPVT), long QT syndrome (LQTS), calcium release deficiency syndrome (CRDS), and atrial fibrillation (AF).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!