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| http://dx.doi.org/10.1186/s12939-020-01297-y | DOI Listing |
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ReAlign-N: an integrated realignment approach for multiple nucleic acid sequence alignment, combining global and local realignments.
NAR Genom Bioinform
December 2024
Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, No.2006, Xiyuan Avenue, Pidu Zone, Chengdu 610054, China.
Ensuring accurate multiple sequence alignment (MSA) is essential for comprehensive biological sequence analysis. However, the complexity of evolutionary relationships often results in variations that generic alignment tools may not adequately address. Realignment is crucial to remedy this issue.
View Article and Find Full Text PDFPATELLOFEMORAL INSTABILITY PART 3 (PATELLOFEMORAL CARTILAGE TREATMENT): STATE OF THE ART.
J ISAKOS
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IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, Milan, Italy.
Cartilage lesions around the knee are common injuries in the orthopedic practice. The spontaneous healing capacity of the articular cartilage is limited, and therefore surgical intervention may be necessary. The goal is to improve patients' symptoms, articular functionality, and potentially delay the progression of knee osteoarthritis.
View Article and Find Full Text PDFDespite a Multifactorial Etiology, Rates of Distal Junctional Kyphosis After Adult Cervical Deformity Corrective Surgery Can be Dramatically Diminished by Optimizing Age Specific Radiographic Improvement.
Global Spine J
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Division of Spine Surgery, Departments of Orthopaedic and Neurological Surgery, NYU Langone Medical Center, NY Spine Institute, New York, NY, USA.
Study Design: Retrospective cohort study of a prospectively collected single-center database.
Objective: Distal Junctional Kyphosis (DJK) is one of the most common complications in adult cervical deformity (ACD) correction. The utility of radiographic alignment alone in predicting and minimizing DJK occurrence warrants further study.
A "rotating menu" of medical uncertainty for families affected by telomere biology disorders: A qualitative interview study.
SSM Qual Res Health
December 2024
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Background: Medical uncertainty may cause distress and challenge medical decision-making for patients with rare diseases and their caregivers. Few studies have examined the experience and management of medical uncertainty in rare disease and the dynamics of multiple medical uncertainty sources, issues, and management strategies.
Objective: We explored the experience and management of uncertainty in individuals with telomere biology disorders (TBDs), a set of rare cancer-prone bone marrow failure syndromes, and their caregivers.
Background: Diabetes can be detected at the primary health-care level, and effective treatments lower the risk of complications. There are insufficient data on the coverage of treatment for diabetes and how it has changed. We estimated trends from 1990 to 2022 in diabetes prevalence and treatment for 200 countries and territories.
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