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Is eating disorders a risk agent for all-cause mortality: a meta-analysis.

Eat Disord

September 2024

Health and wellness research group, Department of Family Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE.

Article Synopsis
  • - This study conducted a systematic review and meta-analysis to examine the risk of mortality associated with eating disorders using data from multiple databases, focusing on three specific types of eating disorders: anorexia nervosa, bulimia nervosa, and eating disorders not otherwise specified.
  • - The findings revealed a significant overall increased risk of mortality for individuals with eating disorders, highlighting an overall Standardized Mortality Ratio (SMR) of 4.42, indicating they are over four times more likely to die compared to the general population.
  • - Anorexia nervosa was found to have the highest mortality risk (SMR 5.31), followed by bulimia nervosa (SMR 2.69) and other specified disorders (SM
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Objective: This primary care study examined time trends in the incidence of anorexia nervosa (AN) and bulimia nervosa (BN) in the Netherlands across four decades.

Methods: A nationwide network of general practitioners, serving approximately 1% of the total Dutch population, recorded newly diagnosed patients with AN and BN in their practices from 1985 to 2019 (2,890,978 person-years). DSM-IV diagnostic criteria were consistently used and the same psychiatrist was responsible for the final diagnostic decision.

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Laxative Abuse Is Associated With a Depleted Gut Microbial Community Structure Among Women and Men With Binge-Eating Disorder or Bulimia Nervosa: The Binge Eating Genetics Initiative.

Psychosom Med

October 2023

From the Department of Nutrition (Igudesman, Reed, Bulik, Carroll), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Medical Epidemiology and Biostatistics (Abbaspour, Bulik) Karolinska Institutet, Stockholm, Sweden; Department of Psychology and Neuroscience (Flatt), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Division of Pediatric Infectious Diseases (Becken), University of Nebraska Medical Center, Omaha, Nebraska; and Department of Psychiatry, University of North Carolina at Chapel Hill (Thornton, Bulik), Chapel Hill, North Carolina.

Objective: This study assessed the associations of binge eating, compensatory behaviors, and dietary restraint with the composition and diversity of the intestinal microbiota among participants with binge-eating disorder or bulimia nervosa.

Methods: We analyzed data from 265 participants aged 18 to 45 years with current binge-eating disorder or bulimia nervosa enrolled in the Binge Eating Genetics Initiative study. We evaluated the associations of binge-eating frequency; presence/absence and frequency of vomiting, laxative use, and compulsive exercise; and dietary restraint with abundances of gut microbial genera, species, and diversity (Shannon diversity, Faith phylogenetic diversity, and Peilou's evenness) from 16S rRNA gene sequencing.

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Eating disorders (EDs) represent a contradictory chapter of clinical psychiatry, i.e., although they are associated with significant prevalence and risks in the long term (including vital risk, especially for anorexia nervosa), the therapeutic resources are minimal and based on low-quality data.

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