AI Article Synopsis
- The study investigates the protective effects of traditional ginseng essence (TEG) against liver damage caused by carbon tetrachloride (CCl) in rats.
- Results indicated that TEG significantly reduced liver injury indicators, improved antioxidant enzyme activity, and decreased lipid accumulation in liver tissues after nine weeks of treatment.
- Histopathological analysis showed less liver fibrosis and lipid accumulation, suggesting that TEG enhances liver health and protects against chemical-induced injury.
Article Abstract
The peroxide produced in the lipid metabolic process attacks liver cells and causes liver injury. Ginsenosides have been shown to have anti-oxidation abilities and to mend myocardial damage. This study evaluated the effect of traditional ginseng essence (TEG) in preventing chemical liver damage induced by carbon tetrachloride (CCl). Forty 8-week-old male Sprague Dawley (SD) rats were divided into five groups: control, liver injury (CCl), and TEG by oral gavage at 0.074, 0.149, or 0.298 g/kg/day for nine weeks. Liver injury biochemical indicators, antioxidant enzyme activity, and lipid contents in liver tissues were evaluated. The liver appearance was observed, and histopathological tests were conducted to estimate whether TEG-antagonized oxidants further ameliorated liver injury. The results show that, after supplementation of TEG for nine consecutive weeks and CCl-induced liver injury for eight weeks, the levels of liver injury biochemical indicators in animal serum decreased significantly, and, in liver tissue, antioxidant activity was significantly improved and accumulation of lipids was decreased. Pathological sections exhibited reduced liver lipid accumulation and fibrosis. As discussed above, TEG can increase the antioxidant capacity in the liver and the maintenance of hepatocyte function, protecting the liver from chemical injury and improving healthcare.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594089 | PMC |
| http://dx.doi.org/10.3390/nu12103214 | DOI Listing |
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