Objectives: Absorbed dose to red marrow (D) can be calculated using blood dosimetry. However, this method is laborious and invasive. Therefore, image-based dosimetry is the method of choice. Nonetheless, the commercial software is expensive. The goal of this work was to develop a simplified excel spreadsheet for image-based radioiodine red marrow dosimetry.
Methods: The serial whole-body images (acquired at 2, 6, 24, 48, and 72 hours) of 29 patients from the routine pretherapeutic dosimetry protocol were retrospectively reanalyzed. The commercial OLINDA/EXM image-based dosimetry software was used to calculate the whole-body time-integrated activity coefficient (TIAC) and D [in terms of absorbed dose coefficient (d)]. For the simplified excel spreadsheet, the wholebody count was obtained from the vendor-supplied software. Then, the TIAC was computed by a fitting time-activity curve using an Excel function. S factor was taken from other publications and scaled according to the patient-specific mass. A comparison of the TIAC and d from both methods was done using a non-inferiority test using a paired t-test or the Wilcoxon signed-rank test.
Results: The TIAC showed no significant difference between both methods (p=0.243). The calculated D from a simplified Excel spreadsheet was assumed to be statistically non-inferior to the commercial OLINDA/EXM image-based dosimetry software with the non-inferiority margin of 0.02 (p<0.05).
Conclusion: The dose assessment from a simplified Excel spreadsheet is feasible and relatively low cost compared to the commercial OLINDA/EXM image-based dosimetry software.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583750 | PMC |
| http://dx.doi.org/10.4274/mirt.galenos.2020.71473 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Large Language Models May Help Patients Understand Peer-Reviewed Scientific Articles About Ophthalmology: Development and Usability Study.
J Med Internet Res
December 2024
Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, Los Angeles, CA, United States.
Background: Adequate health literacy has been shown to be important for the general health of a population. To address this, it is recommended that patient-targeted medical information is written at a sixth-grade reading level. To make well-informed decisions about their health, patients may want to interact directly with peer-reviewed open access scientific articles.
View Article and Find Full Text PDFA comparison of routine [Ga]Ga-PSMA-11 preparation using Locametz and Illuccix kits.
EJNMMI Radiopharm Chem
December 2024
Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI, 48109, USA.
Background: Approval of Locametz and Illuccix kits for the manufacture of [Ga]Ga-PSMA-11 (gallium Ga68 gozetotide), a PET imaging agent for prostate cancer, as well as the corresponding therapeutic ([Lu]Lu-PSMA-617 Pluvicto), has led to a rapid increase in demand for [Ga]Ga-PSMA-11 PET imaging. Radiopharmaceutical manufacturers, using Ge/Ga generators, may decide to adopt Locametz and/or Illuccix kits, which requires a comparison to select the most suitable kit for day-to-day use. The objective of this article is to compare both kits and provide guidance for selecting one for routine use, as well as evaluate labeling consistency of both kits during routine production.
View Article and Find Full Text PDFBackground: Pediatric vaccine clinical trials are crucial for evaluating and ensuring the safety and efficacy of new vaccines for children. However, in low-resource settings like Nepal, where clinical trials are relatively new, recruitment and retention of participants are challenging particularly due to diverse parental backgrounds, motivations and concerns. As such, parental motivations, perceived barriers, and experiences of participating in pediatric vaccine trial in Nepal, which hasn't previously been explored, needs to be understood.
View Article and Find Full Text PDFOne size does not fit all in evaluating model selection scores for image classification.
Sci Rep
December 2024
Computer Science Department, Ruhr West University of Applied Sciences, Bottrop, Germany.
Selecting pretrained models for image classification often involves computationally intensive finetuning. This study addresses a research gap in the standardized evaluation of transferability scores, which could simplify model selection by ranking pretrained models without exhaustive finetuning. The motivation is to reduce the computational burden of model selection through a consistent approach that guides practitioners in balancing accuracy and efficiency across tasks.
View Article and Find Full Text PDFAI-generated estimates of familiarity, concreteness, valence, and arousal for over 100,000 Spanish words.
Q J Exp Psychol (Hove)
December 2024
Department of Experimental Psychology, Ghent University, Gent, Belgium.
This study investigates whether estimates of familiarity, valence, arousal, and concreteness based on artificial intelligence (AI) are useful alternatives to word counts and human ratings in Spanish. We replicate and extend previous findings in English and show that GPT-4o is effective in estimating these word features. Validity checks even suggest that AI-generated estimates sometimes outperform traditional measurements.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!