AI Article Synopsis
- The study evaluated the effectiveness and tolerability of two chemotherapy regimens, S-IROX and modified FOLFIRINOX (mFFX), for advanced pancreatic cancer after patients became resistant to gemcitabine plus nab-paclitaxel.
- A total of 54 patients treated with either regimen showed S-IROX had higher disease control (73.7%) and response rates (10.5%) compared to mFFX (62.2% and 2.7%, respectively), though median progression-free survival and overall survival were not significantly different.
- Both treatments were found to have similar levels of tolerability and effectiveness, with S-IROX showing potential benefits for specific patient subgroups.
Article Abstract
Purpose: The aim of this study was to evaluate the efficacy and tolerability of S-IROX and modified FOLFIRINOX (mFFX) after gemcitabine plus nab-paclitaxel for advanced pancreatic cancer (PC) in the real world setting.
Methods: Consecutive patients receiving S-IROX or mFFX as a second-line chemotherapy for advanced PC refractory to gemcitabine plus nab-paclitaxel were retrospectively studied. Patients were treated every 2 weeks: S-1 40 mg/m was administered orally twice daily on days 1 to 7 in S-IROX and 5-fluorouracil 2400 mg/m was intravenously administered for 46 h without bolus infusion in mFFX, in addition to intravenous oxaliplatin 85 mg/m and irinotecan 150 mg/m on day 1 in both regimens.
Results: Fifty-four patients with advanced PC who received S-IROX (n = 19) or mFFX (n = 35) were retrospectively studied. The disease control rate and response rate were 73.7% and 10.5% in the S-IROX group and 62.2% and 2.7% in the mFFX group, respectively. The median progression free survival (PFS) was 7.8 and 5.7 months in the S-IROX and mFFX groups (p = 0.24). The median overall survival (OS) was 14.2 and 11.5 months in the S-IROX and mFFX groups (p = 0.34). There were no significant differences in the incidences of grade 3-4 adverse effects. The subgroup analyses suggested S-IROX demonstrated favorable OS in patients with PFS ≥6 months of first-line gemcitabine plus nab-paclitaxel (p for interaction = 0.02).
Conclusions: S-IROX and mFFX were similarly tolerable and effective as a second-line chemotherapy in patients with PC refractory to gemcitabine plus nab-paclitaxel.
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| http://dx.doi.org/10.1007/s10637-020-01022-0 | DOI Listing |
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