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Features and results availability of non-commercial Spanish COVID-19 trials: a systematic review of clinical trial registers and corresponding literature.
Eur J Clin Pharmacol
January 2025
Biostatistics and Epidemiology Unit, Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid, Madrid, Spain.
Objectives: This study aimed to characterize non-commercial Spanish COVID-19 trials and to determine the availability of results. Differences in outcomes according to the interventions assessed (medicines, non-medicines) will also be determined.
Methods: This systematic review was conducted in March 2024 by searching non-commercial Spanish COVID-19 trials on four registers (EUCTR, Clinical.
Sociodemographic, behavioral, and clinical risk factors associated with cervical dysplasia: A case-control study.
Medwave
January 2025
Departamento de Medicina y Cirugía Oral, Facultad de Odontología, Universidad Nacional San Luis Gonzaga. Ica, Perú.
Introduction: Cervical dysplasia is a precursor lesion of cervical cancer, one of the leading causes of morbidity and mortality in women, especially in developing countries. This study aimed to identify the risk factors associated with the development of cervical dysplasia in women treated at the Santa María del Socorro Hospital in Ica, Peru, between 2017 and 2019.
Methods: An observational case-control study was conducted with 92 cases of women with confirmed high-grade intraepithelial lesion and 184 controls with consecutive negative results in Pap smears.
Biomarkers.
Alzheimers Dement
December 2024
Cognitive Neuroscience Center, University of San Andrés, Victoria, Buenos Aires, Argentina.
Background: Digital health research on Alzheimer's disease (AD) points to automated speech and language analysis (ASLA) as a globally scalable approach for diagnosis and monitoring. However, most studies target uninterpretable features in Anglophone samples, casting doubts on the approach's clinical utility and cross-linguistic validity. The present study was designed to tackle both issues.
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Alzheimers Dement
December 2024
Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Background: Stress has emerged as a risk factor in the development and progression of Alzheimer's Disease (AD). However, there is limited research on the impact cumulative individual and familial stress has on AD. This study aims to investigate the relationship between stress and AD within a global cohort of underrepresented populations including Black Americans (BAs), Hispanic/Latinos (H/Ls), and Africans (As).
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Alzheimers Dement
December 2024
Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA.
Background: Plasma concentrations of phosphorylated threonine-181 of Tau (pTau181) and the ratio of amyloid beta isoforms Aβ42/Aβ40 are biomarkers for differential diagnosis and preclinical detection of Alzheimer disease (AD). However, assessment of the utility of these biomarkers has been in non-Hispanic, European individuals. Given differences in AD risk across populations, generalizability of these findings is not assured in individuals of diverse ancestries.
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