Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587299 | PMC |
| http://dx.doi.org/10.5888/pcd17.200096 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The spatial landscape of cancer hallmarks reveals patterns of tumor ecological dynamics and drug sensitivity.
Cell Rep
January 2025
Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain; Barcelona Supercomputing Center (BSC), Barcelona, Spain. Electronic address:
Tumors are complex ecosystems of interacting cell types. The concept of cancer hallmarks distills this complexity into underlying principles that govern tumor growth. Here, we explore the spatial distribution of cancer hallmarks across 63 primary untreated tumors from 10 cancer types using spatial transcriptomics.
View Article and Find Full Text PDFPharmacological blocking of microfibrillar-associated protein 4 reduces retinal neoangiogenesis and vascular leakage.
Mol Ther
January 2025
Department of Molecular Medicine, University of Southern Denmark; Odense, 5230, Denmark. Electronic address:
Neovascular age-related macular degeneration and diabetic macular edema are leading causes of vision-loss evoked by retinal neovascularization and vascular leakage. The glycoprotein microfibrillar-associated protein 4 (MFAP4) is an integrin αβ ligand present in the extracellular matrix. Single-cell transcriptomics reveal MFAP4 expression in cell-types in close proximity to vascular endothelial cells including choroidal vascular mural cells and retinal astrocytes and Müller cells.
View Article and Find Full Text PDFReverse-engineering the FLT3-PI3K/AKT axis to enhance TILs function and improve prognosis in ovarian and cervical cancers.
J Ovarian Res
January 2025
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, #128 Shenyang Road, Shanghai, 200090, People's Republic of China.
Background: Ovarian cancers (OC) and cervical cancers (CC) have poor survival rates. Tumor-infiltrating lymphocytes (TILs) play a pivotal role in prognosis, but shared immune mechanisms remain elusive.
Methods: We integrated single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) to explore immune regulation in OC and CC, focusing on the PI3K/AKT pathway and FLT3 as key modulators.
Chemical evolution characteristics and influencing factors of groundwater in the saline and fresh water funnel area in Hengshui City, North China.
Sci Rep
January 2025
School of Urban Geology and Engineering, Hebei GEO University, 050031, Shijiazhuang, China.
Both over-exploitation and exploitation reduction of groundwater can alter the conditions of groundwater recharge and discharge, thereby impacting the overall quality of groundwater. This study utilizes hydrogeochemical methods and statistical analysis to explore the spatial and temporal evolution characteristics and influencing factors of groundwater chemistry in the saline-freshwater funnel area of Hengshui City under exploitation reduction. The results showed that: With the exception of the deep freshwater funnel area in the western region, which exhibits a trend of water quality deterioration (Cl accounted for more than 25%), groundwater quality in the other funnel areas demonstrates an improving trend (HCO[Formula: see text] accounted for more than 25%).
View Article and Find Full Text PDFRethinking the biochar impact on the anaerobic digestion of food waste in bench-scale digester: Spatial distribution and biogas production.
Bioresour Technol
January 2025
Advanced Environmental Biotechnology Centre, Nanyang Environment and Water Research Institute, Nanyang Technological University, 1 Cleantech Loop, Singapore, 637141, Singapore.
The improvement of biogas production in anaerobic digestion (AD) by biochar introduction has been demonstrated. However, the distribution of biochar in the digester and its effect on AD have been seldom explored. In this study, the distribution of biochar and their impact on AD were investigated in a 30 L semi-continuously operated bench-scale anaerobic digester.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!