The autophagy-related genes (ATGs) play important roles in plant growth and response to environmental stresses. () is among the most important oilseed crops, but are largely unknown in this species. Therefore, a genome-wide analysis of gene family () was performed. One hundred and twenty-seven ATGs were determined due to the genome, which belongs to 20 main groups. Segmental duplication occurred more than the tandem duplication in . Ka/Ks for the most duplicated pair genes were less than one, which indicated that the negative selection occurred to maintain their function during the evolution of plants. Based on the results, are involved in various developmental processes and respond to biotic and abiotic stresses. One hundred and seven miRNA molecules are involved in the post-transcriptional regulation of 41 . In general, 127 simple sequence repeat marker (SSR) loci were also detected in . Based on the RNA-seq data, the highest expression in root and silique was related to , while in shoot and seed, it was . The expression patterns of the most were significantly up-regulated or down-regulated responding to dehydration, salinity, abscisic acid, and cold. This research provides information that can detect candidate genes for genetic manipulation in .
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http://dx.doi.org/10.3390/plants9101393 | DOI Listing |
Curr Mol Med
January 2025
Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Ningbo University, No.59 Liuting Street, Haishu District, Ningbo City, Zhejiang Province, 315010, China.
Background: Ovarian cancer is one of the deadliest gynecologic cancers, with chemotherapy resistance as the greatest clinical challenge. Autophagy occurrence is associated with cisplatin (DDP)-resistant ovarian cancer cells. Herein, the role and mechanism of alpha-synuclein (SNCA), the autophagy-related gene, in DDP resistance of ovarian cancer cells are explored.
View Article and Find Full Text PDFJ Cell Mol Med
January 2025
Department of Andrology, The First Hospital of Jilin University, Changchun, China.
Prostate cancer (PCa) is one of the most common cancers in men worldwide. Autophagy-related genes (ARGs) may play an important role in various biological processes of PCa. The aim of this study was to identify and evaluate autophagy-related features to predict clinical outcomes in patients with PCa.
View Article and Find Full Text PDFBiochem Biophys Res Commun
December 2024
Department of Immunology, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China. Electronic address:
The autophagosome is a double-membrane organelle that executes macroautophagy. Previous studies have shown that the autophagosome formation is driven by autophagy-related genes, among which ATG9 is the only conserved transmembrane protein and has been shown to play a critical role in the autophagosome formation. However, how ATG9 binds to the growing autophagosome membrane has remained uncertain.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Bandung Institute of Technology, Bandung, West Java, Indonesia
Background: Emerging research indicates that autophagy, a cellular degradation process, may be triggered by certain immune responses, including those by vaccines. This study aims to examine whether the SARS‐CoV‐2 vaccines, known to induce robust immune activation, can trigger autophagic pathways that facilitate the degradation of amyloid‐beta (Aβ), a pathological feature of Alzheimer’s disease (AD). By applying deep learning techniques to analyze complex immunological and neurological data, this study explores a potentially innovative therapeutic strategy for AD.
View Article and Find Full Text PDFPlant Cell Rep
January 2025
Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresources and College of Biology, Institute of Tropical Agriculture and Forestry, Hainan University, Haikou, 570228, China.
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