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Neurobiological mechanisms of antidepressant properties of psilocybin: A systematic review of blood biomarkers.
Prog Neuropsychopharmacol Biol Psychiatry
January 2025
Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands.
Psilocybin represents a novel therapeutic approach for individuals with major depressive disorder (MDD) who do not respond to conventional antidepressant treatment. Investigating the influence of psilocybin on the pathophysiological processes involved in MDD could enhance our neurobiological understanding of the presumed antidepressant action mechanism. This systematic review aims to summarize the results of human studies investigating changes in blood-based biomarkers of MDD to guide future research on potentially relevant analytes that could be monitored in clinical trials.
View Article and Find Full Text PDFIntroduction: Asthma is a common respiratory condition; however, its symptoms often overlap with other diseases, posing diagnostic challenges. Tracheal stenosis, often seen in patients with a history of intubation, can mimic asthma symptoms, leading to misdiagnosis.
Case Study: This case study discusses a 58-year-old female with hypertension, type 2 diabetes, and obesity.
Joint Anatomical, Histological, and Imaging Investigation of the Midbrain Target Region for Superolateral Medial Forebrain Bundle Deep Brain Stimulation.
Stereotact Funct Neurosurg
November 2024
Department of Stereotactic and Functional Neurosurgery, Medical Center of Freiburg University, Freiburg, Germany.
Introduction: Deep brain stimulation (DBS) of the superolateral branch of the medial forebrain bundle (slMFB) is currently being researched in clinical trials and open case series as a therapeutic option for treatment-resistant major depressive disorder and treatment-resistant obsessive-compulsive disorder (TR-OCD). There are numerous publications describing stimulation in such proximity to the ventral tegmental area (VTA) and open questions remain concerning the stimulation target and its functional environment. As of right now, we are not aware of any publications that compare the typical electrode placements with the histologically supported tractographic depiction of the target structure.
View Article and Find Full Text PDFResuscitative thoracotomy in France: For whom? By whom?
J Visc Surg
December 2024
Service de chirurgie digestive et de l'urgence, CHU de Grenoble-Alpes, université Grenoble-Alpes, CS 10237, 38043 Grenoble cedex, France. Electronic address:
Resuscitative thoracotomy is preferentially addressed to patients with penetrating thoracic injury and suffering from severe treatment-resistant hemodynamic instability, without pulse or in cardiopulmonary arrest for at most 15minutes. It is practicable in an emergency room, or ideally, in an operating theater. The procedure always begins with left anterolateral thoracotomy and can be prolonged through transversal bi-thoracotomy or, more rarely and according to the presumed origin of the hemorrhage, through median sternotomy.
View Article and Find Full Text PDFThe timing and severity of clozapine-associated neutropenia in the US: Is the risk overstated?
Schizophr Res
October 2024
Precision Medicine Center of Excellence in Schizoaffective Disorders, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Article Synopsis
- Concern about clozapine-related neutropenia leads to its underuse, particularly affecting access for individuals of African ancestry who tend to have lower absolute neutrophil counts due to a specific genetic factor.
- A study at Johns Hopkins Medicine analyzed clozapine usage from 2013-2023, identifying patients and examining neutropenia rates and demographic differences, finding no severe cases among 974 patients but noting some developed mild to moderate neutropenia.
- The research highlights a potential issue with current ANC monitoring requirements being overly restrictive, which may hinder the effective use of clozapine for patients who could benefit from it, especially within Black populations.
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