AI Article Synopsis
- Neuromodulation technologies show promise in improving motor functions after spinal cord injury (SCI) by enhancing excitability in the spinal networks below the injury site, independent of brain signals.
- The review assesses how spinal circuits can adapt and reorganize when sensory inputs are present during motor training, leading to potential recovery mechanisms.
- The implications of these findings suggest that future advancements in neuromodulation and rehabilitation can significantly benefit functional recovery, including the development of neuroprosthetics.
Article Abstract
Evidence from preclinical and clinical research suggest that neuromodulation technologies can facilitate the sublesional spinal networks, isolated from supraspinal commands after spinal cord injury (SCI), by reestablishing the levels of excitability and enabling descending motor signals via residual connections. Herein, we evaluate available evidence that sublesional and supralesional spinal circuits could form a after SCI. We further discuss evidence of translesional network reorganization after SCI in the presence of sensory inputs during motor training. In this review, we evaluate potential mechanisms that underlie translesional circuitry reorganization during neuromodulation and rehabilitation in order to enable motor functions after SCI. We discuss the potential of neuromodulation technologies to engage various components that comprise the translesional network, their functional recovery after SCI, and the implications of the concept of translesional network in development of future neuromodulation, rehabilitation, and neuroprosthetics technologies.
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| http://dx.doi.org/10.1177/1073858420966276 | DOI Listing |
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