A new highly oxygenated germacranolide, carcerlane A (), together with four known highly oxygenated germacranolides (-), was isolated from an ethanol extract of the whole plant of var. (C.B.Clarke) Kitam. The structures were determined by HRESIMS and extensive analysis of their spectroscopic data including IR, 1 D and 2 D NMR spectra. To our best knowledge, it was the first time to report the phytochemical investigation on this plant. The anti-Alzheimer's disease (AD) activities of - were evaluated using AD pathological model. All the tested compounds showed that they have the anti-AD bioactivities of delaying worms paralysis.
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| http://dx.doi.org/10.1080/14786419.2020.1833199 | DOI Listing |
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