AI Article Synopsis
- Preclinical studies suggest that progesterone and estrogen affect drug-taking behaviors, including smoking, but clinical research findings are inconsistent due to issues with measuring natural hormone levels.
- Exogenous progesterone shows potential benefits for cognitive function and smoking cessation, while hormonal replacement therapy's impact on smoking is unclear, and oral contraceptives may negatively affect stress and nicotine metabolism.
- More research is needed to clarify how exogenous hormone administration can improve study methods and enhance our understanding of hormones in smoking behavior and cessation efforts.
Article Abstract
Purpose Of Review: Preclinical evidence indicates progesterone and estrogen influence drug-taking behaviors, including nicotine/tobacco. However, clinical research on this relationship is less clear. This lack of clarity may be due to measuring naturally occurring endogenous hormones to examine this relationship, which introduces substantial error. Therefore, the goal of this review is to examine the link between the delivery of exogenous hormones and cigarette smoking-related behavior.
Recent Findings: Exogenous progesterone may have favorable effects on cognition, symptomatology, consumption, and smoking cessation. Hormonal replacement therapy does not have a clear relationship with smoking-related behaviors. Oral contraceptive use may have adverse effects on stress response, nicotine metabolism, and symptomatology. Additional research is needed to explore how the administration of exogenous hormones may (a) strengthen research methodology on this topic, (b) enhance our understanding of the role of progesterone/estrogen on smoking-related behaviors, and (c) improve smoking cessation outcomes.
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| http://dx.doi.org/10.1007/s11920-020-01197-6 | DOI Listing |
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