AI Article Synopsis
- ISM2 is a protein mainly expressed in the placenta, with no prior studies linking it to preeclampsia or choriocarcinoma.
- Researchers conducted a study on women with preeclampsia, gestational hypertension, and normal pregnancies, measuring ISM2 levels and using immunohistochemistry on tissue samples.
- The study found that ISM2 levels were lower in preeclampsia patients compared to controls, suggesting a link to the disease's development, while higher levels in choriocarcinoma indicate a role in cancer-related angiogenesis.
Article Abstract
Introduction: Isthmin 2 (ISM2) is a protein which expression in humans is almost specific to the placenta. There is no previous report in the literature that investigated this protein in preeclampsia or choriocarcinoma.
Methods: We conducted a prospective, cross-sectional study that included women with preeclampsia, gestational hypertension and normotensive pregnancy. We measured serum concentrations of ISM2 protein and performed immunohistochemistry in placenta tissues. We also performed immunohistochemistry of ISM2 in samples from choriocarcinoma and compare with lung, prostate, colon, gastric and breast cancers.
Results: A total of 81 patients were included, 30 with preeclampsia, 21 with gestational hypertension and 30 controls. The ISM2 protein was found to be decreased in patients with preeclampsia compared to the control group (P = 0.036). These results were confirmed by immunohistochemistry. We also found that ISM2 protein was overexpressed in choriocarcinoma.
Discussion: Taken together, our results suggest an angiogenic function for ISM2. Its serum level decreased in our patients with preeclampsia could be reflecting that it is involved in the pathogenesis of the disease; on the other hand its high expression in choriocarcinoma, indicates that ISM2 may play an active role in the angiogenesis of this and other cancers.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567920 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2020.e05096 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Microbiome-derived antimicrobial peptides show therapeutic activity against the critically important priority pathogen, Acinetobacter baumannii.
NPJ Biofilms Microbiomes
September 2024
Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Belfast, UK.
Acinetobacter baumannii is designated by the World Health Organisation as a critical priority pathogen. Previously we discovered antimicrobial peptides (AMPs), namely Lynronne-1, -2 and -3, with efficacy against bacterial pathogens, such as Staphylococcus aureus and Pseudomonas aeruginosa. Here we assessed Lynronne-1, -2 and -3 structure by circular dichroism and efficacy against clinical strains of A.
View Article and Find Full Text PDF: A Comprehensive Review of Its Phytochemical Composition and Pharmacological Activities.
Biomolecules
August 2024
Department of Biology, American University of Beirut, Riad El Solh, Beirut 1107 2020, Lebanon.
(Forsskål and Niebuhr) Ascherson is a small marine seagrass that belongs to the Hydrocharitaceae family. It is native to the Red Sea, Persian Gulf, and Indian Ocean and has successfully invaded the Mediterranean and Caribbean Seas. This article summarizes the pharmacological activities and phytochemical content of , along with its botanical and ecological characteristics.
View Article and Find Full Text PDFSucrose as an electron source for cofactor regeneration in recombinant Escherichia coli expressing invertase and a Baeyer Villiger monooxygenase.
Microb Cell Fact
August 2024
Institute of Molecular Biotechnology, Graz University of Technology, NAWI Graz, Petersgasse 14, 8010, Graz, Austria.
Background: The large-scale biocatalytic application of oxidoreductases requires systems for a cost-effective and efficient regeneration of redox cofactors. These represent the major bottleneck for industrial bioproduction and an important cost factor. In this work, co-expression of the genes of invertase and a Baeyer-Villiger monooxygenase from Burkholderia xenovorans to E.
View Article and Find Full Text PDFRepurposing myoglobin into a carbene transferase for a [2,3]-sigmatropic Sommelet-Hauser rearrangement.
J Inorg Biochem
November 2024
Aix Marseille Univ, CNRS, Centrale Méditerranée, iSm2, Marseille, France; Université de Strasbourg, CNRS, INSERM, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Department of Integrated Structural Biology, Illkirch, France. Electronic address:
New-to-Nature biocatalysis has emerged as a promising tool in organic synthesis thanks to progress in protein engineering. Notably, hemeproteins have been evolved into robust catalysts for carbene and nitrene transfers and related sigmatropic rearrangements. In this work, we report the first example of a [2,3]-sigmatropic Sommelet-Hauser rearrangement initiated by a carbene transfer of the sperm whale myoglobin mutant L29S,H64V,V68F that was previously reported to catalyze the mechanistically similar [2,3]-sigmatropic Doyle-Kirmse rearrangement.
View Article and Find Full Text PDFESCCPred: a machine learning model for diagnostic prediction of early esophageal squamous cell carcinoma using autoantibody profiles.
Br J Cancer
September 2024
College of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan Provinc, China.
Background: Esophageal squamous cell carcinoma (ESCC) is a deadly cancer with no clinically ideal biomarkers for early diagnosis. The objective of this study was to develop and validate a user-friendly diagnostic tool for early ESCC detection.
Methods: The study encompassed three phases: discovery, verification, and validation, comprising a total of 1309 individuals.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!