Background: Alpha amylase inhibitors are used in the treatment of type II diabetes mellitus. and , widely consumed as spices have several medicinal uses which include their traditional use in the management of diabetes. This study was conducted to investigate the alpha amylase inhibitory potential and mode of inhibition of and oils.
Method: Oil was extracted from dried bulb of and by Soxhlet extraction. The α-amylase inhibitory potential of the 2 oils were evaluated. The mode of inhibition of the oils were determined from the lineweaver-burk plot and the kinetic parameters obtained from the lineweaver - burk plot.
Result: oil had 58.13 ± 1.09 and 69.8 ± 1.11 percent inhibition at 5.0 and 7.0% concentrations respectively while oil had 55.45 ± 1.35, 59.73 ± 1.11 and 65.21 ± 1.11 percent inhibition at 5.0, 7.5 and 10% concentrations respectively. The IC values for oil, oil and acarbose were 3.0 ± 0.02%, 4.4 ± 0.03% and 14.1 ± 0.09% respectively. The lineweaver - burk plot showed that the Vmax of the 2 oils did not change when compared with that of the no inhibitor (no oil) but the Km increased.
Conclusion: These findings indicate that and oils are competitive inhibitors of α- amylase and can both be used in the treatment of type II diabetes mellitus. oil is a better inhibitor than
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545766 | PMC |
| http://dx.doi.org/10.1177/1179551420963106 | DOI Listing |
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