AI Article Synopsis
- Simultaneous FDG-PET/fMRI allows researchers to measure brain activity by capturing both glucose uptake and blood flow dynamics in real time.
- The combination of resting-state fMRI and new functional PET measurements helps explore how different brain regions communicate and their metabolic activities.
- In a study with 27 healthy young adults, data from a 95-minute resting scan was collected, offering valuable insights into brain network interactions and aiding in the development of advanced imaging techniques.
Article Abstract
Simultaneous [18 F]-fluorodeoxyglucose positron emission tomography and functional magnetic resonance imaging (FDG-PET/fMRI) provides the capability to image two sources of energetic dynamics in the brain - cerebral glucose uptake and the cerebrovascular haemodynamic response. Resting-state fMRI connectivity has been enormously useful for characterising interactions between distributed brain regions in humans. Metabolic connectivity has recently emerged as a complementary measure to investigate brain network dynamics. Functional PET (fPET) is a new approach for measuring FDG uptake with high temporal resolution and has recently shown promise for assessing the dynamics of neural metabolism. Simultaneous fMRI/fPET is a relatively new hybrid imaging modality, with only a few biomedical imaging research facilities able to acquire FDG PET and BOLD fMRI data simultaneously. We present data for n = 27 healthy young adults (18-20 yrs) who underwent a 95-min simultaneous fMRI/fPET scan while resting with their eyes open. This dataset provides significant re-use value to understand the neural dynamics of glucose metabolism and the haemodynamic response, the synchrony, and interaction between these measures, and the development of new single- and multi-modality image preparation and analysis procedures.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578808 | PMC |
| http://dx.doi.org/10.1038/s41597-020-00699-5 | DOI Listing |
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