With the publication of the first paper describing the biochemical properties of DNA polymerase iota (polɩ), the question immediately arose as to why cells harbor such a low-fidelity enzyme which often violates the Watson-Crick base pairing rules? Yet 20 years after its discovery, the cellular function of polɩ remains unknown. Here, we provide a graphical review of the unique biochemical properties of polɩ and speculate about the cellular pathways in which enigmatic polɩ may participate.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586464 | PMC |
| http://dx.doi.org/10.1016/j.dnarep.2020.102914 | DOI Listing |
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