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Focus on MicroRNAs as Biomarker in Pediatric Diseases. | LitMetric
Background : MiRNAs are a class of small non-coding RNAs that are involved in the post-transcriptional regulation of gene expression. MiRNAs are considered a class of epigenetic biomarkers. These biomarkers can investigate disease at different stages: diagnosis, therapy or clinical follow-up.Objective : The aim of this paper is to highlight the innovative use of miRNAs in several childhood diseases.Methods : We conducted a literature review to search the usage of miRNAs in pediatric clinical routine or experimental trials.Results : We found a possible key role of miRNAs in different pediatric illnesses (metabolic alterations, coagulation defects, cancer).Conclusion : The modest literature production denotes that further investigation is needed to assess and validate the promising role of miRNAs as non-invasive biomarkers in pediatric disorders.
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