AI Article Synopsis
- Carbocyclinone-534 is a newly discovered antibiotic derived from the metabolism of tapinarof.
- The researchers developed a biomimetic total synthesis method for producing this antibiotic in just eight steps using a series of chemical reactions.
- This synthesis method offers direct experimental insights into the biological process that creates carbocyclinone-534.
Article Abstract
Carbocyclinone-534 is a new antibiotic produced after the metabolism of tapinarof. We identify a biomimetic total synthesis of carbocyclinone-534 in eight steps by taking advantage of an intermolecular Diels-Alder homodimerization/dehydrogenation/intramolecular Diels-Alder cycloaddition cascade. This synthetic sequence provides direct experimental evidence for revealing the biosynthetic pathway of carbocyclinone-534.
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| http://dx.doi.org/10.1021/acs.orglett.0c02865 | DOI Listing |
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