Noninflammatory Retiform Purpura: Answer.

Am J Dermatopathol

Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC.

Published: November 2020

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Source
http://dx.doi.org/10.1097/DAD.0000000000001552DOI Listing

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Article Synopsis
  • Occluding vasculopathies are a group of conditions that often cause skin ulcers, particularly leg ulcers.
  • This article focuses on livedoid vasculopathy and calciphylaxis as important types of occlusive vasculopathies relevant for diagnosing leg ulcers.
  • Diagnosis involves identifying specific skin signs, like livedo racemosa, and confirming through tissue samples and lab tests to differentiate from other skin conditions.
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Background: Cutaneous microvascular occlusion syndromes (MOS) present with noninflammatory retiform purpura with variable outcomes that are dependent on the severity, duration, and specific underlying cause. Transient cases are often associated with few sequelae, while severe forms such as symmetrical peripheral gangrene may be associated with amputation and death.

Observations: A middle-aged man developed MOS after exposure to phenylephrine hydrochloride and experienced complete resolution when treatment with the vasopressor was discontinued.

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