Focusing on the current state of the art, this article (a) describes recent advances in the understanding of the pathogenesis of venous thromboembolism (VTE), (b) discusses current approaches for the prevention, diagnosis and treatment of VTE, (c) outlines the role of aspirin for VTE prevention and treatment, and (d) highlights the unmet needs in VTE management and describes novel approaches to address them.
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http://dx.doi.org/10.12688/f1000research.27115.1 | DOI Listing |
ACS Appl Mater Interfaces
January 2025
Ian Potter NanoBiosensing Facility, NanoBiotechnology Research Laboratory, School of Science, RMIT University, Melbourne, Victoria 3000, Australia.
Metal-organic frameworks (MOFs) provide diverse applications across a wide range of scientific disciplines, including drug/nucleic acid (NA) delivery. In the subclass of MOFs, zeolitic imidazolate framework-8 (ZIF-8) is well regarded due to its exceptional physicochemical properties. Biomolecules can be encapsulated and released under precise conditions within ZIF, making it an important material for materials science and biomedical applications.
View Article and Find Full Text PDFJAMA Netw Open
January 2025
Population Policy and Practice, Great Ormond Street UCL Institute of Child Health, London, United Kingdom.
Importance: Intraventricular hemorrhage (IVH) has proven to be a challenging and enduring complication of prematurity. However, its association with neurodevelopment across the spectrum of IVH severity, independent of prematurity, and in the context of contemporary care remains uncertain.
Objective: To evaluate national trends in IVH diagnosis and the association with survival and neurodevelopmental outcomes at 2 years of age.
Importance: This article highlights key National Institutes of Health (NIH) programs, policies, and scientific advances that have informed and improved the health of women and describe the promise and potential of harnessing cutting-edge science and integrative approaches to advance women's health research. Policy updates combined with recent scientific and programmatic initiatives are intended to expand understanding of women's health, deliver diagnostics, and develop preventive approaches and novel therapies to meet critical health needs of contemporary women.
Observations: To benefit all people through the work funded and conducted by the NIH biomedical research enterprise, NIH has implemented policies that broadly expanded the knowledge of human health and disease from the laboratory to the clinic.
J Infus Nurs
December 2024
Author Affiliations: Elaine Marieb College of Nursing, Elaine Marieb Center for Nursing & Engineering Innovation, University of Massachusetts Amherst, Amherst, Massachusetts.
Intravenous pumps (IVPs) deliver IV medications to millions of acute care patients each year and result in many adverse events reported to the US Food and Drug Administration (FDA). Although the use of IVPs has improved overall safety, there are still high rates of error that risk the safety of all patients, especially those of advanced age and those suffering from critical illness. Most of the documented errors are based on clinician reports, although there is reason to believe that errors due to flow rate inaccuracy go undetected and unreported.
View Article and Find Full Text PDFArch Toxicol
January 2025
Department of Integrative Biology, School of Bioscience and Technology, Vellore Institute of Technology (VIT), Vellore, 632014, Tamil Nadu, India.
Snake envenomation presents a significant global health challenge, especially in rural areas of tropical and subtropical regions. Traditional antivenom therapies face limitations related to efficacy, availability, and specificity, prompting a need for novel approaches. Recent advancements in omics technologies, particularly metabolomics and proteomics, have enhanced our understanding of snake venom composition, toxicity, and potential therapeutic strategies.
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