AI Article Synopsis
- Methylphenidate (MPH) is a common ADHD treatment, but there are worries about its effects on growth over time.
- A meta-analysis of 18 studies found that long-term MPH use is linked to small but significant decreases in height and weight in children with ADHD.
- The study suggests that while MPH may affect growth, the overall clinical impact appears minimal, and more extensive research is needed to understand its long-term effects.
Article Abstract
Background: Methylphenidate (MPH) is an efficacious treatment for ADHD but concerns have been raised about potential adverse effects of extended treatment on growth.
Objectives: To systematically review the literature, up to December 2018, conducting a meta-analysis of association of long-term (> six months) MPH exposure with height, weight and timing of puberty.
Results: Eighteen studies (ADHD n = 4868) were included in the meta-analysis. MPH was associated with consistent statistically significant pre-post difference for both height (SMD = 0.27, 95% CI 0.16-0.38, p < 0.0001) and weight (SMD = 0.33, 95% CI 0.22-0.44, p < 0.0001) Z scores, with prominent impact on weight during the first 12 months and on height within the first 24-30 months. No significant effects of dose, formulation, age and drug-naïve condition as clinical moderators were found. Data on timing of puberty are currently limited.
Conclusions: Long-term treatment with MPH can result in reduction in height and weight. However, effect sizes are small with possible minimal clinical impact. Long-term prospective studies may help to clarify the underlying biological drivers and specific mediators and moderators.
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| http://dx.doi.org/10.1016/j.neubiorev.2020.09.031 | DOI Listing |
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