This work investigates the interstitial fluid flow characteristics in a solid tumor with partial fluid leakage at the tumor surface subjected to oscillatory microvascular pressure. Solutions of the pore fluid pressure and velocity in a spherical tumor are obtained using the poroelasticity theory for small strains. It is found that partial fluid leakage at the tumor surface reduces the pore pressure drop and decreases the fluid velocity near the surface compared with those in a tumor with a fully leaking surface. Both the pore pressure and the fluid velocity decrease dramatically with an increase in the vascular frequency. The pore pressure at a vascular frequency of 1 Hz is two orders of magnitude smaller than the amplitude of the vascular pressure, and the fluid velocity at the same frequency is one order of magnitude smaller than that produced by the steady constant vascular pressure. The pore pressure amplitude may reach that of the vascular pressure under the steady state vascular pressure condition.
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http://dx.doi.org/10.1016/j.mvr.2020.104097 | DOI Listing |
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