A new study presents a three-dimensional mechanical model with multiple cell layers to interrogate the flattening of organs during development. This model shows the importance of initial asymmetry and its reinforcement by mechanical feedback within the inner cell walls, not the outer epidermal wall, in guiding organ flattening of organ primordia.
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http://dx.doi.org/10.1016/j.cub.2020.08.027 | DOI Listing |
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