Identification of aberrant hypermethylation in promoter regions of candidate genes to discover potential biomarkers for colorectal cancer. Genes , , , , , and were pre-selected in a bioinformatics study for their hypermethylation status in colorectal cancer. Methylation analysis was performed on 202 cancer tissue specimens to validate candidate genes. Genes and displayed methylation in 95.3 and 99.7% of The Cancer Genome Atlas dataset samples and in 96 and 98% of our experimentally tested samples, respectively. and promoter hypermethylation holds diagnostic biomarker potential in patients with early colorectal cancer.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2217/epi-2020-0118 | DOI Listing |
Publication Analysis
Top Keywords
colorectal cancer
16
biomarkers colorectal
8
candidate genes
8
genes
5
cancer
5
hypermethylated promoters
4
promoters genes
4
genes potential
4
potential novel
4
novel diagnostic
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!