Previous studies across languages (English, Spanish, French) have argued that perceptual salience and cue reliability can explain cross-linguistic differences in early comprehension of verbal agreement. Here we tested this hypothesis further by investigating early comprehension in Greek, where markers have high salience and reliability (compared to Spanish and English) predicting early comprehension, as in French. We investigated two and three-year-old Greek-speaking children's ability to distinguish third person singular and plural agreement in a picture-selection task. We also examined the frequency of these morphemes in child-directed speech to address input effects. Results showed that three-year-olds are sensitive to both singular and plural agreement, earlier than children acquiring English and Spanish, but later than French, and despite singular agreement being more frequent than plural agreement in the child corpus. These findings provide further support for the role of salience and reliability during early acquisition, while highlighting a potential effect of morpheme position.
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http://dx.doi.org/10.1017/S0305000920000628 | DOI Listing |
Nat Commun
December 2024
Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
The lack of a robust system to reproducibly propagate HRV-C, a family of viruses refractory to cultivation in standard cell lines, has substantially hindered our understanding of this common respiratory pathogen. We sought to develop an organoid-based system to reproducibly propagate HRV-C, and characterize virus-host interaction using respiratory organoids. We demonstrate that airway organoids sustain serial virus passage with the aid of CYT387-mediated immunosuppression, whereas nasal organoids that more closely simulate the upper airway achieve this without any intervention.
View Article and Find Full Text PDFElife
December 2024
Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, United States.
Background: Individuals with Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), display clear signs of immune dysregulation, including high rates of autoimmunity and severe complications from infections. Although it is well established that T21 causes increased interferon responses and JAK/STAT signaling, elevated autoantibodies, global immune remodeling, and hypercytokinemia, the interplay between these processes, the clinical manifestations of DS, and potential therapeutic interventions remain ill defined.
Methods: We report a comprehensive analysis of immune dysregulation at the clinical, cellular, and molecular level in hundreds of individuals with DS, including autoantibody profiling, cytokine analysis, and deep immune mapping.
Front Neurosci
December 2024
Department of Otorhinolaryngology Head and Neck Surgery, Tianjin First Central Hospital, Tianjin, China.
Background: Cochlear implants (CIs) have the potential to facilitate auditory restoration in deaf children and contribute to the maturation of the auditory cortex. The type of CI may impact hearing rehabilitation in children with CI. We aimed to study central auditory processing activation patterns during speech perception in Mandarin-speaking pediatric CI recipients with different device characteristics.
View Article and Find Full Text PDFInt J Womens Health
December 2024
Department of Infection Control, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, People's Republic of China.
Purpose: This study aims to examine the risk factors for catheter-associated urinary tract infection (CAUTI) following radical hysterectomy for cervical cancer (CC). Furthermore, the study seeks to develop a visual model that can effectively assist physicians in improving their proficiency in diagnosing, treating, and preventing CAUTIs.
Patients And Methods: 48 subjects who developed CAUTI postoperatively were assigned to the infection group.
Front Oncol
December 2024
Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Hidradenocarcinoma (HAC) is a rare neoplasm that typically occurs in the head and neck region but seldom affects the chest wall. Histopathology and immunohistochemistry remain essential for diagnosing HAC, although their clinical utility in determining metastasis can be limited. Given the pathological rarity and histopathological heterogeneity of HAC, we report a case demonstrating the utility of positron emission tomography/computed tomography (PET/CT) combined with immunohistochemical examination for the accurate diagnosis and staging of HAC.
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