Objective: To evaluate an influence of intracerebral L-lactate concentration on sleep-wake cycle.

Material And Methods: Twenty adult male white rats preliminary implanted (under general anesthesia) with the electrodes for neocortical EEG and a single cannula to a lateral ventricle were used as subjects. A 5 µl bolus of either saline or a solution of sodium L- or D-lactate (0.1 mg, 0.2 M, Sigma-Aldrich) was injected through the cannula and followed by a 6-hr recording.

Results And Conclusion: Administration of L-lactate does not influence sleep-wake cycle of experimental animals. At the same time, its artificial optical analog D-lactate induces the significant (as compared to the control) decrease in wake (34.8% to 26.5%) and increase in slow wave sleep (57.4% to 69.2%). It has been suggested that D-lactate may be the antagonist of one or several L-lactate receptors.

Download full-text PDF

Source
http://dx.doi.org/10.17116/jnevro202012009222DOI Listing

Publication Analysis

Top Keywords

[d-lactate novel
4
novel somnogenic
4
somnogenic factor?]
4
factor?] objective
4
objective evaluate
4
evaluate influence
4
influence intracerebral
4
intracerebral l-lactate
4
l-lactate concentration
4
concentration sleep-wake
4

Similar Publications

A new method for quantifying glyoxalase II activity in biological samples.

Biol Methods Protoc

September 2024

Department of Chemistry, College of Science, University of Babylon, Hillah City 51002, Iraq.

Glyoxalase II (Glo II) is a crucial enzyme in the glyoxalase system, and plays a vital role in detoxifying harmful metabolites and maintaining cellular redox balance. Dysregulation of Glo II has been linked to various health conditions, including cancer and diabetes. This study introduces a novel method using 2,4-dinitrophenylhydrazine (2,4-DNPH) to measure Glo II activity.

View Article and Find Full Text PDF

Buqi-Huoxue-Tongnao decoction drives gut microbiota-derived indole lactic acid to attenuate ischemic stroke via the gut-brain axis.

Chin Med

September 2024

Guangdong Provincial Key Laboratory of New Drug Screening, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism and Guangdong-Hong Kong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, Guangdong, China.

Background: Ischemic stroke belongs to "apoplexy" and its pathogenesis is characterized by qi deficiency and blood stasis combining with phlegm-damp clouding orifices. Buqi-Huoxue-Tongnao decoction (BHTD) is a traditional Chinese medicine formula for qi deficiency, blood stasis and phlegm obstruction syndrome. However, its efficacy and potential mechanism on ischemic stroke are still unclear.

View Article and Find Full Text PDF
Article Synopsis
  • Vaginitis is linked to harmful bacteria and a lack of good lactobacilli, prompting researchers to explore lactobacilli supplementation as a treatment strategy.
  • The study involved sequencing the genomes of 98 isolated strains to identify candidates for probiotics based on their genetic profiles, which included factors like metabolite production and resistance to harsh conditions.
  • Two exceptional strains, LG55-27 and TM13-16, were effective in reducing bacterial vaginosis in a rat model, demonstrating their potential for both oral and vaginal treatment options.
View Article and Find Full Text PDF

Glycolic acid and D-lactate-putative products of DJ-1-restore neurodegeneration in FUS - and SOD1-ALS.

Life Sci Alliance

August 2024

Translational Neurodegeneration Section "Albrecht Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, Rostock, Germany

Amyotrophic lateral sclerosis (ALS) leads to death within 2-5 yr. Currently, available drugs only slightly prolong survival. We present novel insights into the pathophysiology of (SOD1)- and in particular (FUS)-ALS by revealing a supposedly central role of glycolic acid (GA) and D-lactic acid (DL)-both putative products of the Parkinson's disease associated glyoxylase DJ-1.

View Article and Find Full Text PDF

This study aimed to explore the safety and properties of IDCC 3401 as a novel probiotic strain via genomic and phenotypic analyses. In whole-genome sequencing, the genes associated with antibiotic resistance and virulence were not detected in this strain. The minimum inhibitory concentration test revealed that IDCC 3401 was susceptible to all the antibiotics tested, except for kanamycin.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!