AI Article Synopsis
- White matter hyperintensities (WMH) are linked to brain aging and can signal disruptions in white matter pathways, potentially affecting behavior.
- This study evaluated 60 asymptomatic individuals aged 50 to 80, comparing those with WMH to those without, using neuropsychological tests and advanced MRI scans to assess WMH and hippocampal size.
- Results indicated that individuals with WMH showed signs of subclinical apathy and anxiety, along with reduced hippocampal volume, highlighting potential risks for future cognitive decline and dementia.
Article Abstract
White matter hyperintensities (WMH) are associated with brain aging and behavioral symptoms as a possible consequence of disrupted white matter pathways. In this study, we investigated, in a cohort of asymptomatic subjects aged 50 to 80, the relationship between WMH, hippocampal atrophy, and subtle, preclinical cognitive and neuropsychiatric phenomenology. Thirty healthy subjects with WMH (WMH+) and thirty individuals without (WMH-) underwent comprehensive neuropsychological and neuropsychiatric evaluations and 3 Tesla Magnetic Resonance Imaging scan. The presence, degree of severity, and distribution of WMH were evaluated with a semi-automated algorithm. Volumetric analysis of hippocampal structure was performed through voxel-based morphometry. A multivariable logistic regression analysis indicated that phenomenology of subclinical apathy and anxiety was associated with the presence of WMH. ROI-based analyses showed a volume reduction in the right hippocampus of WMH+. In healthy individuals, WMH are associated with significant preclinical neuropsychiatric phenomenology, as well as hippocampal atrophy, which are considered as risk factors to develop cognitive impairment and dementia.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712953 | PMC |
| http://dx.doi.org/10.3390/jpm10040172 | DOI Listing |
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