A loading dose and short-term administration of oral ribavirin significantly improved symptoms and signs of influenza type A or B infection in 25 patients. The antiviral effect was not significant. No adverse clinical effects or significant laboratory values were observed. Oral treatment of patients with influenza A or B infection might be possible with ribavirin.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC174922PMC
http://dx.doi.org/10.1128/AAC.31.8.1285DOI Listing

Publication Analysis

Top Keywords

oral ribavirin
8
ribavirin treatment
4
treatment influenza
4
influenza loading
4
loading dose
4
dose short-term
4
short-term administration
4
administration oral
4
ribavirin improved
4
improved symptoms
4

Similar Publications

Background And Aims: Pan-genotypic ribavirin-free oral direct-acting antivirals, including the glecaprevir/pibrentasvir combination, are recommended for the treatment of most patients with chronic hepatitis C virus (HCV) infection. In Romania, the HCV-infected patient population receiving glecaprevir/pibrentasvir is not well characterized and data on treatment effectiveness is lacking. The ODYSSEY study aimed to provide insights into the characteristics and treatment outcomes of HCV-infected Romanian patients receiving 8-week therapy with glecaprevir/pibrentasvir.

View Article and Find Full Text PDF

Dengue (DENV) and Zika virus (ZIKV), transmitted by Aedes mosquitoes, pose significant public health challenges. Effective treatments for these viruses remain elusive, highlighting the urgent need for new efficient antiviral therapies. This study explores prodigiosin, a microbial tripyrrole pigment, as an antiviral agent against both DENV and ZIKV employing advanced analytical approaches which integrate molecular docking, CASTp 3.

View Article and Find Full Text PDF

The Mediterranean fruit fly is an agricultural pest of a wide variety of fruit crops. An effective method to counteract them in the field is through the application of the sterile insect technique, which requires the mass-production of sterile males. The presence of pathogens, and specifically viruses, threatens the well-being of mass-reared insects generating an interest on the development of strategies for viral elimination or containment.

View Article and Find Full Text PDF
Article Synopsis
  • Respiratory syncytial virus-associated acute respiratory infection (RSV-ARI) is increasingly affecting adults, leading to serious health issues, as shown in a study of 275 hospitalized patients.
  • In this study, 11.2% of patients experienced poor outcomes, with certain factors increasing their risk, such as cognitive impairment, use of anticoagulants, and low oxygen saturation ratios upon hospital admission.
  • Interestingly, receiving the flu vaccine in the current season was found to reduce the risk of poor outcomes, underscoring the importance of early risk assessment for RSV-ARI in the emergency department.
View Article and Find Full Text PDF

A diverse group of RNA viruses have the ability to gain access to the central nervous system (CNS) and cause severe neurological disease. Current treatment for people with this type of infection is generally limited to supportive care. To address the need for reliable antivirals, we utilized a strategy of lethal mutagenesis to limit virus replication.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!