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Drivers and barriers to the choice of production systems among smallholder pig farmers: Evidence from Northern Uganda.
Heliyon
January 2025
Department of Rural Development and Agribusiness, Faculty of Agriculture and Environment, Gulu University, P.O Box 166, Gulu, Uganda.
Pork consumption has risen significantly in many emerging nations, prompting diverse pig production systems. This study explored the drivers and barriers to the choices of pig production systems and the challenges confronting pig farmers in Northern Uganda. Data were collected from 240 pig farmers using a structured questionnaire and analyzed using multinomial logit regression.
View Article and Find Full Text PDFThe economic burden of breast cancer in western Iran: a cross-sectional cost-of-illness study.
J Health Popul Nutr
January 2025
Social Determinants of Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Background: Breast cancer is a significant global health challenge, affecting millions annually and imposing a considerable burden on healthcare systems and economies worldwide. This cross-sectional study aims to determine the economic impact of breast cancer in Lorestan Province, western Iran.
Methods: A retrospective cost-of-illness analysis utilizing a cross-sectional design was performed from November 2023 to July 2024.
SERCA2a dysfunction in the pathophysiology of heart failure with preserved ejection fraction: a direct role is yet to be established.
Heart Fail Rev
January 2025
School of Cardiovascular and Metabolic Medicine & Sciences, King's College London British Heart Foundation Centre of Research Excellence, London, UK.
With rising incidence, mortality and limited therapeutic options, heart failure with preserved ejection fraction (HFpEF) remains one of the most important topics in cardiovascular medicine today. Characterised by left ventricular diastolic dysfunction partially due to impaired Ca homeostasis, one ion channel in particular, SarcoEndoplasmic Reticulum Ca-ATPase (SERCA2a), may play a significant role in its pathophysiology. A better understanding of the complex mechanisms interplaying to contribute to SERCA2a dysfunction will help develop treatments targeting it and thus address the growing clinical challenge HFpEF poses.
View Article and Find Full Text PDFComposite Graphene for the Dimension- and Pore-Size-Mediated Stem Cell Differentiation to Bone Regenerative Medicine.
ACS Appl Mater Interfaces
January 2025
School of Pharmacy, Weifang Medical University, Weifang 261053, Shandong PR China.
As one of the most promising means to repair diseased tissues, stem cell therapy with immense potential to differentiate into mature specialized cells has been rapidly developed. However, the clinical application of stem-cell-dominated regenerative medicine was heavily hindered by the loss of pluripotency during the long-term in vitro expansion. Here, a composite three-dimensional (3D) graphene-based biomaterial, denoted as GO-Por-CMP@CaP, with hierarchical pore structure (micro- to macropore), was developed to guide the directional differentiation of human umbilical cord MSCs (hucMSCs) into osteoblasts.
View Article and Find Full Text PDFPurinergic inhibitory regulation of esophageal smooth muscle is mediated by P2Y receptors and ATP-dependent potassium channels in rats.
J Physiol Sci
January 2025
Department of Basic Veterinary Science, Laboratory of Physiology, Joint Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, 501-1193, Gifu, Japan; Department of Basic Veterinary Science, Laboratory of Physiology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, 501-1193, Gifu, Japan; Division of Animal Medical Science, Center for One Medicine Innovative Translational Research (COMIT), Gifu University Institute for Advanced Study, 1-1 Yanagido, 501-1193, Gifu, Japan.
Purines such as ATP are regulatory transmitters in motility of the gastrointestinal tract. The aims of this study were to propose functional roles of purinergic regulation of esophageal motility. An isolated segment of the rat esophagus was placed in an organ bath, and mechanical responses were recorded using a force transducer.
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