In this work, the postmortem interval is estimated by means of Bayesian inference using rectal temperature data from a published database. First, a systematic analysis of the uncertainties in each of the model parameters is carried out in order to assess their relative influences on the postmortem interval uncertainty. Then, the method is applied to the whole database and proves to be more reliable than the well-established nomogram method. Moreover, the result of the Bayesian inference process is the full posterior probability distribution of the postmortem interval, which provides more information than a simple point estimate or a time interval. This distribution can be used to assign probabilities to specific time intervals that may arise in a criminal investigation. The application of this statistical analysis can be extended to any method of estimating the postmortem interval.
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http://dx.doi.org/10.1016/j.forsciint.2020.110505 | DOI Listing |
Ann Neurol
January 2025
Research Unit of Neurology, Neurophysiology and Neurobiology, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.
Objective: Despite diagnostic criteria refinements, Parkinson's disease (PD) clinical diagnosis still suffers from a not satisfying accuracy, with the post-mortem examination as the gold standard for diagnosis. Seminal clinicopathological series highlighted that a relevant number of patients alive-diagnosed with idiopathic PD have an alternative post-mortem diagnosis. We evaluated the diagnostic accuracy of PD comparing the in-vivo clinical diagnosis with the post-mortem diagnosis performed through the pathological examination in 2 groups.
View Article and Find Full Text PDFBiomedicines
January 2025
Faculty of Law and Criminology, Maastricht University, Minderbroedersberg 4-6, 6211 LK Maastricht, The Netherlands.
The excitability of skeletal muscle is a less-known post-mortem supravital phenomenon in human bodies, and it can be used to estimate the post-mortem interval. We conducted a field study in the Netherlands to investigate the applicability of muscle excitability (SMR) by mechanical stimulation for estimating the post-mortem interval in daily forensic practice. Knowledge concerning the post-mortem cell mechanisms accounting for the post-mortem excitability of skeletal muscle is lacking.
View Article and Find Full Text PDFBiomedicines
January 2025
Institute of Legal Medicine, Department of Medical and Surgical Sciences, "Magna Graecia" University, 88100 Catanzaro, Italy.
Background/objectives: Differential diagnosis of sudden cardiac death (SCD) remains challenging, particularly in cases lacking evident structural abnormalities. Cardiac markers have been proposed as useful tools for this differentiation in forensic contexts. However, key issues include the influence of postmortem interval (PMI) on marker stability and the limitations of traditional approaches that focus on pericardial fluid, which requires invasive sampling compared to peripheral blood.
View Article and Find Full Text PDFSci Justice
January 2025
Department of Forensic Medicine, Soochow University, Ganjiang East Road, Suzhou, China. Electronic address:
The age of the oldest immature insects present on a cadaver is typically used by forensic entomologists to estimate the minimum postmortem interval (PMI). The green bottle fly, Lucilia sericata (Meigen, 1826), known for its widespread distribution and necrophagy, is of considerable significance in forensic science. This study aimed to investigate potential regional developmental disparities between populations of L.
View Article and Find Full Text PDFSci Justice
January 2025
Laboratory of Criminalistics, Adam Mickiewicz University in Poznań, al. Niepodległości 53, Poznań 61-714, Poland; Centre for Advanced Technologies, Adam Mickiewicz University in Poznań, ul. Uniwersytetu Poznańskiego 10, Poznań 61-614, Poland.
While estimating postmortem interval (PMI) ambient temperature plays a pivotal role, so its reconstruction is crucial for forensic scientists. The recommended procedure is to correct temperatures from the nearest meteorological station based on measurements from the death scene; typically applying linear regression. Recently, there have been attempts to use different algorithms, that can improve that correction, for example GAM algorithm.
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