AI Article Synopsis
- Bone metastasis disrupts normal bone remodeling, leading to changes in bone structure, density, and overall quality.
- Osteolytic metastatic disease negatively affects both the organic and mineral components of bone tissue, resulting in decreased bone quality and mechanical performance.
- Future research should focus on understanding how cancer treatments impact bone quality in metastasized areas to improve treatment strategies.
Article Abstract
Purpose Of Review: Skeletal metastasis involves the uncoupling of physiologic bone remodeling resulting in abnormal bone turnover and radical changes in bony architecture, density, and quality. Bone strength assessment and fracture risk prediction are critical in clinical treatment decision-making. This review focuses on bone tissue and structural mechanisms altered by osteolytic metastasis and the resulting changes to its material and mechanical behavior.
Recent Findings: Both organic and mineral phases of bone tissue are altered by osteolytic metastatic disease, with diminished bone quality evident at multiple length-scales. The mechanical performance of bone with osteolytic lesions is influenced by a combination of tissue-level and structural changes. This review considers the effects of osteolytic metastasis on bone biomechanics demonstrating its negative impact at tissue and structural levels. Future studies need to assess the cumulative impact of cancer treatments on metastatically involved bone quality, and its utility in directing multimodal treatment planning.
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| http://dx.doi.org/10.1007/s11914-020-00633-z | DOI Listing |
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