This cross-sectional study examines the prevalence of asymptomatic and presymptomatic severe acute respiratory syndrome coronavirus 2 infection in skilled nursing facilities.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573793 | PMC |
http://dx.doi.org/10.1001/jamainternmed.2020.5664 | DOI Listing |
Neurobiol Dis
January 2025
Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China; National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China. Electronic address:
Background: Investigating brain metabolic networks is crucial for understanding the pathogenesis and functional alterations in Creutzfeldt-Jakob disease (CJD). However, studies on presymptomatic individuals remain limited. This study aimed to examine metabolic network topology reconfiguration in asymptomatic carriers of the PRNP G114V mutation.
View Article and Find Full Text PDFBMC Public Health
January 2025
Department of Infectious Diseases, Nanning Center for Disease Control and Prevention, Nanning, 530023, China.
Introduction: COVID-19 has caused tremendous hardships and challenges around the globe. Due to the prevalence of asymptomatic and pre-symptomatic carriers, relying solely on disease testing to screen for infections is not entirely reliable, which may affect the accuracy of predictions about the pandemic trends. This study is dedicated to developing a predictive model aimed at estimating of the dynamics of COVID-19 at an early stage based on wastewater data, to assist in establishing an effective early warning system for disease control.
View Article and Find Full Text PDFJ Neurointerv Surg
December 2024
Neurology, Mayo Clinic in Florida, Jacksonville, Florida, USA
Background: The majority of patients with spontaneous intracranial hypotension (SIH) are symptomatic. Some patients are discovered incidentally. The proportion of asymptomatic SIH has never been defined.
View Article and Find Full Text PDFBrain
December 2024
Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, 40139, Italy.
Evidence from neuropathological cohorts indicates that a CSF α-synuclein (α-syn) seed amplification assay (SAA) may provide quantitative kinetic parameters correlating with α-syn pathology burden in patients with Lewy body disease (LBD). Studies are needed to assess their longitudinal trend during the pre-symptomatic and clinical disease phases and their correlation with measures of disease progression. We aimed to assess the baseline α-syn CSF SAA kinetic parameters, their longitudinal variations and associations with clinical outcomes in a cohort of longitudinally repeatedly sampled Lewy Body disease patients, including clinically unimpaired (asymptomatic LBD) and neurologically impaired individuals.
View Article and Find Full Text PDFJ Med Econ
December 2025
Novartis Gene Therapies Switzerland GmbH, Rotkreuz, Switzerland.
Aims: Spinal muscular atrophy (SMA) is a rare genetic disorder characterized by progressive muscle weakness, atrophy, respiratory failure, and in severe cases, infantile death. Early detection and treatment before symptom onset may substantially improve outcomes, allowing patients to achieve age-appropriate motor milestones and longer survival. We assessed the cost-utility of newborn screening (NBS) for SMA in Japan.
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